Abstract: 　　Objective To analyze the colorectal cancer screening of community residents in Pudong New Area from 2013 to 2023, and provide reference for the promotion and strategy optimization of colorectal cancer screening programs. Methods The residents aged 50-74 years in the colorectal cancer screening of Pudong New Area in Shanghai were recruited in this analysis from 2013 to 2023. The situation of primary screening and colonoscopy in the community was described, and the results of different age groups in primary screening and colonoscopy surveys were conducted. The Chi-square test was used to compare the differences between groups. Results From 2013 to 2023, 907, 030 residents were screened in Pudong New Area, of which 183, 724 were positive, and the positive rate was 20.3%, with the lowest in the 50-54 age group and the highest in the 70-74 age group. The positive rate was higher in men than in women. The overall colonoscopy rate was 27.1%, with the highest rates in men and women in the 50-54 and 55-59 age groups, respectively. A total of 19, 094 cases of intestinal lesions were found by colonoscopy. Among them, there were 1, 147 cases of colorectal cancer, accounting for 6.0%, and the population detection rate was 126.5/100, 000. In addition, 4, 751 cases of precancerous lesions were found, accounting for 24.9%, and the detection rate was 523.8/100, 000.
　　Conclusion The effect of colorectal cancer screening among residents of Pudong New Area is significant. Measures should be taken to optimize the screening strategy based on age differences and increase the participation rate of primary screening and colonoscopy, to achieve the best effect of local colorectal cancer prevention and treatment.