Abstract: The increasingly innovative cancer prevention and treatment strategies have achieved remarkable results in the prevention and treatment of various malignant tumors, while the rising trend of incidence and mortality of pancreatic cancer (PC) has not yet seen a significant turnaround. The clarification of the material basis of traditional Chinese medicine (TCM) syndromes can contribute to the multidisciplinary integrated diagnosis and treatment of PCpancreatic cancer. Long term clinical practice and research have confirmed that The damp-heat syndrome is the core syndrome of PCpancreatic cancer patients, .and have a crucial material basis of inflammatory microenvironment, accordingly, formula with the efficacy of Hheat-clearing and dampness-removing therapy can inhibit the malignant phenotypes by remodelling the tumor microenvironment. Conventional therapy plus with the heat-clearing and dampness-removing formula can make PC patients a better quality of life and significantly prolonged their survival time. can improve the quality of life of pancreatic cancer patients and prolong their survival time. Through the establishment of a standardized animal model of the damp-heat syndrome for basic research, it is found that inflammatory microenvironment is an important material basis of damp-heat syndrome. Clinical transformation research shows that The systemic inflammatory response index (SIRI) is intimately correlated with the cytokines changes underlying the damp-heat syndrome, and can be used to direct PC prognosis assessment. In the future, as an objective biomarker of the damp-heat syndrome. Thethe PC diagnosis and treatment of pancreatic cancer based on SIRI classification willfurther distinguishes the effective patients subgroup of patients responsive totreated with heat-clearing and dampness-removing therapy. In the future, tTaking damp-heat syndrome as the corestarting point to explore, the research on the whole period of syndrome evolution throughout the course of PCpancreatic cancer will contribute to syndrome-based TCM precision treatment of PCpancreatic cancer with TCM.