Abstract:
Objective To compare the association of the incidence and mortality of leukemia and the human development index (HDI) in different countries or regions in 2022, and the trend of leukemia incidence and mortality with age in countries with different HDI levels.
Methods GLOBOCAN 2022 data related to leukemia incidence and mortality in different countries or regions worldwide and HDI were evaluated by Pearson correlation analysis and Kruskal–Wallis test. The incidence and mortality rates of each age and the age change trend were analyzed using the Joinpoint Regression model.
Results Age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and mortality to incidence ratio (M/I) were statistically significantly different among the four groups of HDI countries (P<0.001). HDI was positively correlated with ASIR and ASMR and negatively correlated with M/I. Among all ages, ASIR and ASMR of leukemia of the four groups had similar trends with age, and the risk of leukemia was high at ages less than 15 and more than 40. The incidence of leukemia in all age groups in China differed from those in other countries with high HDI, while the mortality rate was lower than those in other countries with high HDI.
Conclusion Countries or regions with higher HDI have higher ASIR and ASMR and lower M/I because of their better medical condition.
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