CD47分子在弥漫大B细胞淋巴瘤肿瘤微环境中的研究进展

Research Advances on CD47 Molecules in Tumor Microenvironment of Diffuse Large B-cell Lymphoma

摘要: 弥漫大B细胞淋巴瘤（DLBCL）是成年人常见的高度侵袭性恶性血液肿瘤。DLBCL为一种高度异质性淋巴瘤，患者在分子生物学特征、临床表现和预后方面均存在巨大差异。目前越来越多的证据表明，肿瘤微环境对DLBCL的发生、发展发挥着重要的作用。CD47分子是一种整合素相关蛋白，在DLBCL细胞中过度表达，并在淋巴瘤免疫逃逸中起关键作用。本文拟就CD47分子相关信号通路、在DLBCL肿瘤微环境中的作用和DLBCL中靶向CD47分子的治疗策略等方面的研究进展进行综述。

Abstract: Diffuse large B-cell lymphoma (DLBCL) is a common, highly aggressive and heterogeneous hematologic malignancy in adults. Patients with DLBCL have substantially differences in molecular biological characteristics, clinical manifestations, and prognosis. Increasing evidence shows that the tumor microenvironment plays an important role in the occurrence and development of DLBCL. CD47, an integrin related protein, is overexpressed in DLBCL cells and plays a key role in immune escape of lymphoma. This work reviews the research progress of CD47 in DLBCL TME in terms of CD47-related signal pathway, CD47 role in DLBCL TME, and therapeutic strategies targeting CD47 in DLBCL TME.