表观弥散系数与胶质瘤IDH-1/1p19q基因型的相关性研究

孙鹏飞; 牟福玲; 马莉; 付正丰

doi:10.3971/j.issn.1000-8578.2023.22.0698

表观弥散系数与胶质瘤IDH-1/1p19q基因型的相关性研究

Correlation Between Apparent Diffusion Coefficient and IDH-1/1p19q Genotype of Glioma

摘要

摘要:
目的探讨ADC值与胶质瘤IDH-1/1p19q基因型间的相关性。
方法回顾性分析2013年3月—2020年12月经病理证实的69例WHOⅡ /Ⅲ级神经胶质瘤患者的MRI和分子病理学检测结果，采用ROC曲线评估ADC值对胶质瘤基因型（IDH-1、1p19q）的诊断性能。
结果 IDH-1突变组ADC_mean、ADC_min、rADC_mean、rADC_min均分别显著高于IDH-1野生组（P < 0.05、P < 0.01、P < 0.05、P < 0.01），以rADC_min0.979×10³mm²/s为阈值诊断IDH-1突变型与IDH-1野生型胶质瘤的效能最高（AUC=0.770），其敏感度、特异性分别为84.61%和59.09%。
结论 ADC可以作为无创性预测IDH-1突变型与野生型Ⅱ/Ⅲ级胶质瘤的影像学生物标志物。

Abstract:
Objective To investigate the correlation between ADC value and glioma IDH-1/1p19q genotype.
Methods The MRI features and molecular pathological results of 69 patients with pathologically confirmed diagnosis of WHO grade Ⅱ/Ⅲ glioma between March 2013 and December 2020 were retrospectively analyzed. The diagnostic performance of ADC values on glioma genotypes (IDH-1, 1p19q) was evaluated using the ROC curve of the subjects' working characteristics.
Results The ADCmean, ADC_min, rADC_mean, and rADC_min in the IDH-1 mutation group were significantly higher than those in the IDH-1 wild group (P < 0.05, P < 0.01, P < 0.05, P < 0.01). The use of the rADC_min threshold (0.979×10³mm²/s) had the highest efficacy (AUC=0.770) for diagnosis of IDH-1 mutant and IDH-1 wild-type gliomas as well as sensitivity and specificity of 84.61% and 59.09%, respectively.
Conclusion ADC can be used as an imaging biomarker for noninvasive prediction of IDH-1 mutant and wild-type Ⅱ /Ⅲ gliomas.

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