Abstract: Glioma is the most common primary malignant brain tumor with high recurrence and mortality rate. It is difficult to cure only relying on surgical resection, and comprehensive treatment options must be adopted. With the development of molecular and immunological research, novel therapy options represented by tumor-treating fields, targeted therapy and immunotherapy for glioma are gradually increasing, and some new progress has been made. This review will present the important achievements in the treatment of glioma in recent years and prospects for the future development.