Abstract: In recent years, immunotherapy has made revolutionary breakthroughs in the field of lung cancer and has become an indispensable treatment for patients with advanced NSCLC. More patients treated with immunotherapy have achieved long-term survival. At present, immunotherapy is still a hot research hotspot. In order to better understand the development and changes of immunotherapy for advanced NSCLC, this article systematically and comprehensively reviews the clinical research progress of immunotherapy.