钙结合蛋白S100A16在胰腺癌中的表达及临床意义

赵素月; 张玲; 郑莹; 姚丽; 王乾合; 李迅; 朱克祥

doi:10.3971/j.issn.1000-8578.2021.21.0380

钙结合蛋白S100A16在胰腺癌中的表达及临床意义

Expression and Clinical Significance of S100A16 in Pancreatic Cancer

摘要

摘要:
目的探讨S100A16在胰腺癌中的表达及其临床意义。
方法免疫组织化学法检测S100A16蛋白在胰腺癌和胰腺癌旁组织的表达情况，分析S100A16阳性表达与患者临床病理参数和预后的关系。PPI预测与S100A16有直接相互作用的蛋白关系网络。
结果 S100A16在癌组织中表达的阳性率明显高于癌旁组织（P=0.001），血管浸润、淋巴结转移的患者S100A16表达更高。胰腺癌患者的总体生存时间与肿瘤大小、TNM分期和S100A16表达水平相关。多因素分析显示S100A16表达水平是胰腺癌患者预后的独立危险因素，S100A16高表达患者死亡风险增加1.5倍。PPI预测S100A16与S100A14、IL36G、PITX1、PERP在相互作用网络中具有重要作用。
结论 S100A16高表达的胰腺癌患者预后差，S100A16阳性表达是胰腺癌的独立预后指标。

Abstract:
Objective To investigate the expression of S100A16 in pancreatic cancer and its clinical significance.
Methods Immunohistochemical experiment was used to detect the expression of S100A16 protein in pancreatic cancer tissues and adjacent tissues, and we analyzed the relation between S100A16 positive expression and clinicopathological parameters, prognosis of pancreatic cancer patients. PPI was used to predict a protein relationship network that directly interacted with S100A16.
Results The positive rate of S100A16 expression in cancer tissues was significantly higher than that in adjacent tissues (P=0.001). S100A16 expression was higher in patients with vascular infiltration and lymph node metastasis. The overall survival time of patients with pancreatic cancer was related to tumor size, TNM stage and S100A16 expression level. Multivariate analysis showed that the expression level of S100A16 was an independent risk factor for the prognosis of pancreatic cancer patients, and the risk of death in patients with high S100A16 expression increased by 1.5 times. PPI predicted that S100A16 and S100A14, IL36G, PITX1, PERP played an important role in the interaction network.
Conclusion Pancreatic cancer patients with high S100A16 expression have poor prognosis. The positive expression of S100A16 is an independent prognostic indicator.

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