Abstract: The treatment of tumor has a strong timeliness and periodicity. Due to the duration of COVID-19 outbreak of is uncertain, patients with malignant tumors may have recurrent or progressive disease if they are not treated effectively for a long time. Several studies have shown that delayed chemotherapy and endocrine therapy may have adverse effects on the prognosis of cancer patients. Under the epidemic situation, it has become the key problem to be solved urgently by oncologists that how to better serve cancer patients, prevent and control the infection of cancer patients and their families, how to adjust and optimize the hospital treatment process, so as to ensure the scientific and orderly development of clinical work, and minimize the impact of the epidemic on the treatment of cancer patients. This paper focuses on effectively guiding the emergency management, diagnosis and treatment process, reasonable follow-up, scientific epidemic prevention, reducing the risk of transmission and paying close attention to the mental health of tumor patients, to provide the reference for improving the prognosis of tumor patients during the epidemic situation.