Neuropilin-1在非小细胞肺癌患者外周血Treg、PDC细胞中的表达及临床意义

施星月; 陈翀; 刘峰林; 吕帝; 徐杰; 韩正祥

doi:10.3971/j.issn.1000-8578.2020.19.1411

Neuropilin-1在非小细胞肺癌患者外周血Treg、PDC细胞中的表达及临床意义

Neuropilin-1 Expression in Treg and PDC Cells in Peripheral Blood of Non-small Cell Lung Cancer Patients and Clinical Significance

摘要

摘要:
目的探讨NRP-1在非小细胞肺癌患者外周血Treg、PDC细胞中的表达及临床意义。

方法收集49例确诊为非小细胞肺癌患者的外周血，33例健康体检者作为对照组，流式细胞仪检测Treg、PDC细胞上NRP-l的表达。

结果 NRP-1在NSCLC患者外周血Treg细胞的表达率明显高于健康体检者（P < 0.05）；NRP-1在NSCLC患者外周血Treg中的表达与肿瘤最大径、有无淋巴结转移、TNM分期、分化程度有关（P < 0.05）；NRP-1在NSCLC患者外周血PDC中的表达与肿瘤最大径、有无淋巴结转移、TNM分期有关（P < 0.05）。

结论 NRP-1在外周血Treg、PDC细胞的表达可能与非小细胞肺癌免疫调节相关，可能作为用于预测NSCLC患者预后的肿瘤标志物，并有可能成为肺癌治疗的新靶点。

Abstract:
Objective To investigate Neuropilin-1 expression in Treg and PDC cells in peripheral blood of non-small cell lung cancer patients and clinical significance.

Methods We collected the peripheral blood of 49 diagnosed non-small cell lung cancer patients, and 33 healthy subjects were taken as control group. The expression of NRP-1 on Treg and PDC cells in peripheral blood were detected by flow cytometry.

Results The expression rate of NRP-1 in Treg cells of NSCLC patients was significantly higher than that of healthy subjects (P < 0.05). The expression of NRP-1 in Treg cells of NSCLC patients was correlated with the maximum diameter of tumor, lymph node metastasis, TNM stage and differentiation degree (P < 0.05); the expression of PDC was related to the maximum diameter of the tumor, lymph node metastasis and TNM staging(P < 0.05).

Conclusion The expression of NRP-1 in peripheral blood Treg and PDC cells may be associated with immunoregulation of non-small cell lung cancer. It may be a tumor marker for predicting the prognosis of NSCLC patients, and a new target for lung cancer treatment.

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