Abstract: The classical Wnt signaling pathway receptor inhibitors are composed of secreted frizzled-related proteins (SFRPs) and the Dickkopf family (Dkk). SFRPs inhibit wnt/β-catenin signaling by sequestering Wnt from the active receptor complexes. In tumor progression, epigenetic silencing of SFRPs promoter by hypermethylation seems to occur in all tumor types. SFRPs are closely related with the pathological progress and prognosis of female malignant tumor. In order to solve the problem of targeted therapy, it is of great significance to study the mechanism of SFRPs for female malignant tumors. In this paper, we review the research progress of Wnt signaling pathway and important antagonist SFRPs family in female malignant tumor.