PD-1和PD-L1与胃癌患者预后相关性的Meta分析

王玉丰; 姚南; 王军; 闵光涛

doi:10.3971/j.issn.1000-8578.2020.19.0950

PD-1和PD-L1与胃癌患者预后相关性的Meta分析

Prognostic Role of PD-1 and PD-L1 Expression in Gastric Cancer Patients: A Meta-analysis

摘要

摘要:
目的系统评价PD-1和PD-L1的表达对胃癌患者预后的影响。
方法对PubMed、Web of Science、Cochrane Library、中国生物医学数据库（CBM）、Embase、中国知网（CNKI）等数据库进行文献检索。纳入研究为PD-1/PD-L1表达与胃癌患者预后关系的队列研究。采用RevMan 5.3软件对总生存期（OS）进行Meta分析。
结果共纳入10项（3 093例胃癌患者）符合条件的队列研究。单因素和多因素分析显示，PD-1和PD-L1的表达与胃癌患者预后无明显相关性，PD-1的高表达与淋巴结转移（^N+）有显著相关性，PD-L1的高表达与胃癌晚期（Ⅲ~Ⅳ）有显著相关性。
结论 PD-1和PD-L1表达与胃癌患者预后无明显相关性。

Abstract:
Objective To systematically evaluate the effect of PD-1 and PD-L1 expression on the prognosis of gastric cancer patients.
Methods A comprehensive literature review was conducted in PubMed, Web of Science, Cochrane Library, China Biology Medicine Database (CBM), Embase and China National Knowledge Infrastructure (CNKI) databases. The cohort studies about the association of PD-1 and PD-L1 expression with the prognosis of GC patients were identified and included. RevMan 5.3 software was used to perform the meta-analysis for overall survival (OS).
Results We included 10 eligible cohort studies comprising 3093 patients with GC. Univariate and multivariate analyses indicated no significant correlation of PD-1 and PD-L1 expression with the prognosis of GC patients, however, high PD-L1 and PD-1 expression were significantly correlated with advanced stages (Ⅲ-Ⅳ) of GC and lymph node metastasis(N+), respectively.
Conclusion There is no significant correlation of PD-1 and PD-L1 expression with the prognosis of gastric cancer patients.

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