男性与绝经后女性乳腺癌患者的预后分析

吴颖; 成芳

doi:10.3971/j.issn.1000-8578.2020.19.0747

男性与绝经后女性乳腺癌患者的预后分析

吴颖,
成芳

Prognosis of Male and Postmenopausal Female Breast Cancer Patients

WU Ying,
CHENG Fang

摘要

摘要:
目的比较男性乳腺癌（MBC）与绝经后女性乳腺癌（FBC）患者的预后。
方法收集经手术确诊的50例无远处转移MBC患者及512例无远处转移FBC患者的临床病理资料。采用Kaplan-Meier法绘制生存曲线，用Log rank检验分析各曲线之间的差异。采用Cox比例风险分析方法，对有差异的亚类变量进行生存分析。MBC与绝经后的FBC组采用倾向得分匹配及Cox回归分析。
结果 ER/PR在MBC患者中的表达率高于FBC患者（χ²=30.651, P=0.000；χ²=26.909, P=0.000），HER-2阳性表达率较FBC患者低（χ²=24.274, P=0.000）。单因素分析结果表明，MBC患者的OS与绝经前期FBC患者相似（P=0.268），但与绝经后FBC患者差异有统计学意义（P=0.005）；Cox回归显示MBC患者比绝经后FBC患者预后差（P=0.000）。
结论与绝经前后的FBC患者相比，MBC患者表现出较高的ER、PR阳性和较低的HER-2阳性表达率，且MBC患者的OS比绝经后FBC患者低。

Abstract:
Objective To compare the prognosis between male breast cancer(MBC) and postmenopausal female breast cancer(FBC) patients.
Methods We collected 50 MBC and 512 FBC patients without distant metastasis diagnosed by surgery. Survival curves were plotted using the Kaplan-Meier method, and the differences between the curves were analyzed by Log rank test. Survival analysis was performed on the subgroup variables with differences using the Cox proportional hazard analysis method. MBC and the postmenopausal FBC groups used propensity score matching and Cox regression analysis.
Results Compared with FBC patients, the expression rates of ER/PR were higher (χ²=30.651, P=0.000; χ²=26.909, P=0.000) and the positive expression rate of HER-2 was lower (χ²=24.274, P=0.000) in MBC patients. Univariate analysis showed that the OS of MBC patients was similar to that of premenopausal FBC patients (P=0.268), but lower than that of postmenopausal FBC patients (P=0.005); Cox regression analysis showed that MBC patients had poorer prognosis than postmenopausal FBC patients (P=0.000).
Conclusion Compared with post-menopausal FBC patients, MBC patients have higher ER/PR positive and lower HER-2 positive expression rate. And the OS of MBC patients is lower than that of postmenopausal FBC patients.

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