胰腺癌中Circ_0001946的表达及其与患者预后的相关性

邓颖; 白义凤; 杨兰; 王林; 周晓刚

doi:10.3971/j.issn.1000-8578.2020.19.0611

胰腺癌中Circ_0001946的表达及其与患者预后的相关性

Circ_0001946 Expression and Its Correlation with Prognosis of Pancreatic Cancer Patients

摘要

摘要:
目的探讨Circ_0001946在胰腺癌患者中的表达及其与患者预后的相关性。
方法 qRT-PCR法检测Circ_0001946在胰腺癌患者组织及血清标本中的表达, Chi-Square检验分析Circ_0001946与各临床病理参数之间的关系; Kaplan-Meier法分析Circ_0001946的表达与生存时间及预后的关系, 单因素及多因素Cox分析影响胰腺癌患者预后的因素, ROC曲线分析其作为胰腺癌早期诊断生物标志物的效能。
结果 Circ_0001946在胰腺癌患者组织和血清中高表达, 差异有统计学意义(均P < 0.001)。Circ_0001946与脉管癌栓、淋巴结转移、CA199的表达及疾病分期显著相关(均P < 0.05)。血清Circ_0001946表达与AFP的量呈正相关关系(r=0.765, P=0.000)。血清Circ_0001946作为诊断胰腺癌血清标志物的ROC曲线下面积为0.805(95% CI:0.754~0.927, P=0.000)。高表达Circ_0001946的患者总生存时间及无进展生存时间均较低表达者明显缩短(均P=0.000)。单因素及多因素Cox分析结果显示, 疾病分期、Circ_0001946表达及脉管癌栓是胰腺癌患者预后的独立影响因素。
结论 Circ_0001946在胰腺癌患者中高表达, 与患者的预后相关。

Abstract:
Objective To investigate the prognostic significance of Circ_0001946 expression in pancreatic cancer patients.
Methods The expression of Circ_0001946 in pancreatic cancer tissues and serum samples were detected by qRT-PCR, and the relation between Circ_0001946 and various clinicopathological parameters was analyzed by Chi-Square test. Kaplan-Meier method was used to analyze the relation between Circ_0001946 expression and survival time and prognosis. Univariate and multivariate Cox proportional risk models were used to analyze the factors affecting the prognosis of pancreatic cancer patients, and ROC curve was used to analyze its effect as a biomarker for early diagnosis of pancreatic cancer.
Results Circ_0001946 was highly expressed in pancreatic cancer tissues and serum (all P < 0.0001). Circ_0001946 was significantly associated with vascular thrombosis, lymphatic metastasis, CA199 expression and disease stage (all P < 0.05). Serum Circ_0001946 expression was positively correlated with AFP (r=0.765, P=0.000). The area under the ROC curve of Circ_0001946 as a serum marker for the diagnosis of pancreatic cancer was 0.805(95% CI:0.754-0.927, P=0.000). The overall survival and progressive-free survival of patients with high Circ_0001946 expression were significantly shorter than those with low Circ_0001946 expression (all P=0.000). Univariate and multivariate Cox regression analyses showed that disease stage, Circ_0001946 expression and vascular thrombus were independent prognostic factors for pancreatic cancer patients.
Conclusion Circ_0001946 is highly expressed in pancreatic cancer tissues and related to the prognosis of patients.

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