Abstract:
Objective This study aimed to explore the status quo, hot topics, and future prospects in the field of tumor hypoxia by scientometric analysis.
Methods The literatures about tumor hypoxia were downloaded from the Web of Science Core Collection from inceptions to Dec.31st. 2018. We used CiteSpace 5.4.R1, VOSviewer 1.6.10 and Excel 2016 to analyze literature information, such as country, institution, author, keywords and references.
Results A total of 4399 papers about tumor hypoxia were identified, involving 20157 authors from 3604 institutions in 84 countries. Vaupel P, Harris AL and Dewhirst MW published the most literatures. United States, China and United Kingdom contributed the most publications. The three most contributed institutions are the University of Toronto, Stanford University and Oxford University. International Journal of Radiation Oncology Biology Physics (n=175, IF2017=5.554), Cancer Research (n=144, IF2017=9.13) and Radiotherapy Oncology (n=114, IF2017=4.942) are the most productive journals. The main hot topics in tumor hypoxia field are tumor hypoxic cells and cytokines, tumor hypoxia therapy, tumor hypoxia diagnosis, tumor hypoxia prognosis.
Conclusion Developed countries in Europe and America are dominant in the field of tumor hypoxia research. The diagnosis and treatment of tumor hypoxic is still a difficult problem, especially how to overcome the drug resistance caused by tumor hypoxic.
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