Abstract: Cyclooxygenase 2 (COX2) can promote the synthesis of prostaglandins through metabolism, and is highly expressed in various tumor tissues including ovarian cancer. It can affect the occurrence and development of tumors in different ways by regulating downstream metabolites. It stimulates tumor cell proliferation and migration, promotes angiogenesis, inhibits apoptosis, plays an important role in tumor progression and may provide new ideas for tumor therapy.