Abstract: Similar to epithelial cells of endometrial carcinoma, stromal cells, as the major cells in tumor microenvironment, also express estrogen receptor (ER) and are regulated by estrogen. In the roles of estrogen and tumor suppressor genes, stromal cells are closely related to the proliferation, invasion and metastasis of tumor cells. The study of the signal pathways in stromal cells provides new evidence to explore the pathogenesis of estrogen and progesterone imbalance, tumor recurrence, chemotherapy resistance and so on.