Objective To analyze the incidence and characteristics of multiple myeloma in Shenyang from 2009 to 2014, and provide scientific evidence for the prevention and treatment of multiple myeloma.

Methods The data of multiple myeloma cases in Shenyang Cancer Registry were collected and sorted, and the incidence rate, standardized incidence rate and composition ratio were calculated.

Results The incidence of multiple myeloma in Shenyang from 2009 to 2014 was 1.70/100, 000, the standardization rate was 0.72/100, 000, ranking third in malignant tumors in the blood system; the incidence rate in the male was 1.88/100, 000, and the standardization rate was 0.76/100, 000; the incidence rate in the female was 1.53/100, 000, and the standardization rate was 0.69/100, 000. The incidence rate in the male was higher than that in the female. The median age of onset was 62 years old, and the tumor was mostly occurred in 50-79 years old, accounting for 84.57% of the total number of cases. In the past 6 years, the incidence rate in 2014 was 1.14 times that of 2009, and the incidence rate showed an upward trend (P < 0.01). The incidence rate increased rapidly from the age of 45, the highest incidence(7.22/100, 000) was found in the ≥70-year-old group.

Conclusion The incidence of multiple myeloma in Shenyang is mainly in the middle-aged and elderly population. Although the incidence rate is not high, it shows an upward trend.