Abstract: Gadd45 protein is a stress protein that responds to the environment and plays an important role in the regulation of various cell functions such as DNA repair, cell cycle and senescence and genotoxic stress. These proteins include three subtypes: α, β and γ. A large number of studies have shown that they are involved in the regulation of various signaling pathways in tumor cells, which are closely related to the occurrence and development of tumors, and their expression are closely related to tumor prognosis. In this paper, we briefly introduce and elaborate the research progress of Gadd45 protein family in tumor development in recent years.