Abstract: Malignant tumor is are a kind of high-energy metabolic disease. Due to the role of malignant tumors themselves, the human body's stress response to malignant tumors and the measures in the anti-cancer treatment process lead to the special characteristics of cancer patients, such as lipolysis and increased fatty acids oxidation, decreased lean tissue group, insulin resistance, and protein metabolism disorders etc. A large number of metabolites, such as lipopolysaccharide (LPS), lactic acid, arachidonic acid metabolite (PGE2), free fatty acid (FFA), etc., often induce chronic low-grade inflammation. Many tumors occur in the areas of infection, chronic irritation and inflammation, so the influence of the inflammatory microenvironment on tumors has become the focus in the field of scientific research. In the process of tumor body metabolism, many inflammatory mediators are involved, so this paper summarizes the relationship between tumor energy metabolism characteristics, tumor metabolic abnormalities and related inflammatory mediators.