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石汉平. 重视肿瘤生酮治疗的研究[J]. 肿瘤防治研究, 2018, 45(4): 193-198. DOI: 10.3971/j.issn.1000-8578.2018.18.0233
引用本文: 石汉平. 重视肿瘤生酮治疗的研究[J]. 肿瘤防治研究, 2018, 45(4): 193-198. DOI: 10.3971/j.issn.1000-8578.2018.18.0233
SHI Hanping. Putting More Efforts on Cancer Ketogenic Therapy Research[J]. Cancer Research on Prevention and Treatment, 2018, 45(4): 193-198. DOI: 10.3971/j.issn.1000-8578.2018.18.0233
Citation: SHI Hanping. Putting More Efforts on Cancer Ketogenic Therapy Research[J]. Cancer Research on Prevention and Treatment, 2018, 45(4): 193-198. DOI: 10.3971/j.issn.1000-8578.2018.18.0233

重视肿瘤生酮治疗的研究

Putting More Efforts on Cancer Ketogenic Therapy Research

  • 摘要: 肿瘤细胞Warburg效应为肿瘤生酮治疗奠定了坚实的理论基础,大量研究发现生酮疗法是肿瘤治疗的一个有效手段,生酮治疗可以直接抑制肿瘤生长、增强放化疗效果、提高生活质量、延长生存时间;既可以独立使用,也可以与肿瘤治疗其他方法联合。但是不同肿瘤对生酮治疗反应差异显著,机制不明。肿瘤生酮治疗目前以细胞株及其荷瘤动物研究较多,临床上以病例报告为主,缺乏设计严谨的对照研究。为了更好地推动肿瘤治疗的进步与发展,改善我国肿瘤治疗现状,笔者呼吁高度重视生酮疗法等代谢调节治疗,加快转化医学研究,加强临床随机对照研究,探讨生酮治疗疗效差异的原因及其机制,寻找新的、能够指导生酮饮食(ketogenic diet, KD)治疗的分子标志物,为精准筛选生酮治疗对象提供分子标志、建立预测肿瘤生酮治疗敏感度的分子诊断方法,发掘提高肿瘤生酮治疗疗效的干预靶点,从而进一步提高肿瘤治疗效果。

     

    Abstract: Warburg effect provides a substantial theoretical basis for cancer ketogenic therapy (CKT). Previous basic and clinical studies have reported that CKT effectively inhibit cancer growth, enhance chemo-radiotherapy efficacy, improve quality of life and prolong survival time. However, different cancers respond to CKT differently, the underlying mechanism of this heterogeneity remains unclear. CKT can be used independently or combined with other anti-cancer therapies. At present, the studies of CKT mainly conducted in cancer cell lines and corresponding cancer-carried animals, but not in patients. Although some clinical case reports have been known, well-designed clinical trials were still lacking. In order to impel cancer treatment and upgrade its current status, we should put more efforts on metabolic regulation therapy such as CKT, speed up translational medicine research, and reinforce CKT randomized controlled trial to identify the cause of the difference in sensitivity to CKT and its mechanism. It will provide insights into seeking the new biomarkers for CKT candidates, build up the molecular diagnosis methods for predicting the CKT sensitivity and explore the new targets for enhancing CKT efficacy to further optimize precise CKT and greatly improve efficacy of cancer therapy.

     

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