Objective To observe the states of hepatitis B virus infection and the expression levels of HBsAg and HBsAb in patients with colon cancer, and to analyze their correlation with the staging and prognosis of colon cancer.

Methods We collected 85 cases of colon cancer treated in Fujian Provincial Hospital. SPSS 16.0 software was used to retrospectively study the possible influence of hepatitis B virus infection on the infiltration depth, regional lymph node metastasis and distant metastasis in patients with colon cancer.

Results There was no statistically significant difference between the states of hepatitis B virus infection and the depth (T), the regional lymph node metastasis (N) of colon cancer (P=0.331, P=0.098). However, the metastatic disease of regional lymph node in subgroup of hepatitis-B-positive colon cancer was significantly lower than that in hepatitis-B-negative colon cancer(8.1% vs. 17.8%). The level of serum HbsAb in patients without regional lymph node metastasis was higher than that with regional lymph node metastasis (240.111 mIU/ml vs. 178.161 mIU/ml). There was statistically significant difference between the states of hepatitis B virus infection and the distant metastasis (M), liver metastasis (P < 0.001). Meanwhile, both subgroups of positive hepatitis B with infection and vaccine showed significant statistical differences when comparing with hepatitis B negative in the event of the probability of liver metastases (P=0.039 and P < 0.001).

Conclusion The high expression of serum HBsAb might have a potential inhibitory effect on region lymph node metastases in patients with colon cancer. The state of positive hepatitis B expression shows a significantly negative correlation with distant metastases, especially liver metastases. The states of hepatitis B virus infection and the levels with serum HbsAg/HbsAb influence the staging and prognosis of patients with colon cancer significantly.