Abstract:
Objective To investigate the value of 18F-FDG distribution in differentiation diagnosis of high metabolic lung lesions.
Methods We included 102 patients who had lung lesions and underwent PET/CT in this study. The lesions had high and inhomogeneous FDG uptake. All the lesions had pathology results with puncture or surgery. Lung cancer group included 71 cases, inflammatory lesions group included 31 cases. The SUVmax ratio of the proximal/distal part of the lesion (P/D value) was measured and calculated. The ratios were divided into two types, P/D > 1 or P/D < 1. The difference between the two groups was compared by Chi-square test.
Results Lung cancer group was mainly with P/D > 1, accounting for 91.5% (65/71), inflammatory lesions group was mainly with P/D < 1, accounting for 80.6% (25/31), the difference between the two groups is statistically significant (P < 0.001).
Conclusion The FDG activation distribution in lung cancer is higher in proximal part, while that in inflammatory lesion is higher in distal part. The FDG activation distribution is valuable for high metabolic lung lesions, to reduce the false positive diagnosis of 18F-FDG PET/CT.
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