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胸段食管鳞癌手术治疗或根治性放化疗后复发和生存分析

李绪渊, 罗何三, 王鸿彪, 徐绮腻, 杜泽森

李绪渊, 罗何三, 王鸿彪, 徐绮腻, 杜泽森. 胸段食管鳞癌手术治疗或根治性放化疗后复发和生存分析[J]. 肿瘤防治研究, 2017, 44(4): 286-289. DOI: 10.3971/j.issn.1000-8578.2017.04.010
引用本文: 李绪渊, 罗何三, 王鸿彪, 徐绮腻, 杜泽森. 胸段食管鳞癌手术治疗或根治性放化疗后复发和生存分析[J]. 肿瘤防治研究, 2017, 44(4): 286-289. DOI: 10.3971/j.issn.1000-8578.2017.04.010
LI Xuyuan, LUO Hesan, WANG Hongbiao, XU Qi'ni, DU Zesen. Recurrence and Survival of Thoracic Esophageal Squamous Cell Carcinoma Treated with Surgery or Definitive Chemoradiation Therapy[J]. Cancer Research on Prevention and Treatment, 2017, 44(4): 286-289. DOI: 10.3971/j.issn.1000-8578.2017.04.010
Citation: LI Xuyuan, LUO Hesan, WANG Hongbiao, XU Qi'ni, DU Zesen. Recurrence and Survival of Thoracic Esophageal Squamous Cell Carcinoma Treated with Surgery or Definitive Chemoradiation Therapy[J]. Cancer Research on Prevention and Treatment, 2017, 44(4): 286-289. DOI: 10.3971/j.issn.1000-8578.2017.04.010

胸段食管鳞癌手术治疗或根治性放化疗后复发和生存分析

详细信息
    作者简介:

    李绪渊(1984-),男,主治医师,主要从事晚期肿瘤的内科治疗

    通讯作者:

    徐绮腻,E-mail: xuqini@csco.org.cn

  • 中图分类号: R735.1

Recurrence and Survival of Thoracic Esophageal Squamous Cell Carcinoma Treated with Surgery or Definitive Chemoradiation Therapy

More Information
  • 摘要:
    目的 

    分析经手术治疗或根治性放化疗的胸段食管鳞癌患者的复发部位和生存时间特征。

    方法 

    回顾性分析胸段食管鳞癌患者的复发和生存时间,应用Kaplan-Meier法分析生存时间,Cox回归模型进行多因素预后分析。

    结果 

    本研究纳入586例胸段食管鳞癌患者,其中手术组334例,放化疗组252例。手术组共有129例复发(局部区域复发36例,远处转移93例),放化疗组共有118例复发(局部区域复发79例,远处转移39例),两组复发部位的构成比差异有统计学意义(χ2=37.75,P < 0.01)。手术组和放化疗组的中位总生存时间分别为39.5月和23.5月,两者的差异具有统计学意义(P < 0.01)。

    结论 

    胸段食管鳞癌手术治疗后复发以远处转移为主,根治性放化疗后的复发则以局部区域复发为主。手术治疗的生存结果优于根治性放化疗。

     

    Abstract:
    Objective 

    To investigate the site of recurrence and overall survival (OS) in the patients with thoracic esophageal squamous cell carcinoma treated with surgery or definitive chemoradiation therapy (CRT).

    Methods 

    We retrospectively reviewed the recurrence and survival time of the patients with primary esophageal squamous cancer. OS was calculated using the Kaplan-Meier method. Multivariate analysis to determine the independent prognostic factors was performed by the Cox regression model.

    Results 

    A total of 334 patients treated with surgery and 252 treated with definitive CRT were included in this analysis. A total of 129 (36 locoregional and 93 distant) and 118 (79 locoregional and 39 distant) patients experienced the recurrence in the surgery and CRT groups, respectively (χ2=37.75, P < 0.01). The median OS were 39.5 and 23.5 months in the surgery and CRT groups, respectively (P < 0.01).

    Conclusion 

    The sites of recurrence differ between surgery and CRT on the patients with thoracic esophageal squamous cell carcinoma. Surgery is associated with improved overall survival, compared with definitive CRT.

     

  • 图  1   手术组和放化疗组的生存曲线

    Figure  1   Survival curves of surgery and chemoradio-therapy (CRT) groups

    表  1   586例食管鳞癌患者特征

    Table  1   Characteristics of 586 patients with esophageal squamous cell carcinoma

    下载: 导出CSV

    表  2   手术组和放化疗组亚组生存分析

    Table  2   Subgroup survival analysis of surgery and chemoradiotherapy groups

    下载: 导出CSV

    表  3   手术组和放化疗组患者预后的多因素分析

    Table  3   Multivariate analysis of surgery and chemoradic-therapy groups

    下载: 导出CSV
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出版历程
  • 收稿日期:  2016-07-18
  • 修回日期:  2016-12-06
  • 网络出版日期:  2024-01-12
  • 刊出日期:  2017-04-24

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