氨基酸转运体组分SLC3A2在肿瘤发生发展中的作用

Research Advances of Solute Carrier Family 3 Member 2 (SLC3A2) in Tumor

摘要: SLC3A2（solute carrier family 3 member 2）是来自SLC3家族的一种Ⅱ型跨膜糖蛋白，是氨基酸转运体（heteromericamino acid transports, HATs）的重链组成部分。HATs在细胞中广泛表达并介导了几乎所有必需氨基酸的跨膜转运，保证细胞内氨基酸水平的稳定，对维持细胞正常的生物学功能具有重要作用。越来越多的研究报道，SLC3A2在多种肿瘤中高表达并参与细胞的恶性转化，然而其具体作用机制仅有初步报道尚未阐明。现就SLC3A2的结构、功能及其在肿瘤发生发展过程中的作用机制等综述如下。

Abstract: Solute carrier family 3 member 2 (SLC3A2) is a member of type Ⅱ transmembrane glycoprotein of the SLC3 family and a component of heteromericamino acid transports (HATs). While widely expressed in cells, HATs mediate the transmembrane transport of all essential amino acids and maintain the intracellular stability of amino acid concentrations, which is important to the normal function of cells. Researches show that SLC3A2 is highly expressed in various tumor cells and involved in the malignant transformation of cells.However, the mechanisms are still lacking. In this review, we will discuss the advances in the structure and function of SLC3A2 and its mechanism in tumor occurrence and development.