Effect of FDG-PET/CT in Diagnosis, Staging and Prognosis of Pancreatic Cancer: A Meta-analysis
-
摘要:目的
系统评价FDG-PET/CT在胰腺癌诊断、分期及预后预测中的作用。
方法对数据库PubMed、Ovid、Cochrane Library、CNKI和VIP进行计算机检索,筛选相关文献后提取数据、根据QUADAS进行质量评估并采用Meta-Disc和Stata进行数据分析。
结果胰腺癌诊断、分期和预后相关文献共42篇纳入研究。Meta分析结果显示,FDG-PET/CT对胰腺癌的诊断、淋巴结转移和远期转移诊断敏感度合并和特异性合并分别为0.93(95%CI: 0.92~0.94)、0.65(95%CI: 0.56~0.74)和0.82(95%CI: 0.71~0.90),其对应的特异性合并分别为0.73(95%CI: 0.70~0.76)、0.86(95%CI: 0.79~0.91)和0.95(95%CI: 0.91~0.98)。预后分析结果显示,总生存期(HR合并=1.96, 95%CI: 1.52~2.52)和无进展生存期(HR合并=2.26, 95%CI: 1.33~3.83)在高低SUVmax组间差异有统计学意义。
结论FDG-PET/CT可作为胰腺癌诊断和总生存期预测分析的重要影像学工具,但其在胰腺癌分期中的作用仍待进一步研究。
Abstract:ObjectiveTo assess the potential role of deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the diagnosis, staging and prognosis of pancreatic cancer using Meta-analysis.
MethodsComputer-based retrieval was conducted on PubMed, Ovid, Cochrane Library, CNKI and VIP to search reports about diagnosis, staging and prognosis of pancreatic cancer, collected data and evaluated the quality based QUASAD. All calculations were performed by Meta-Disc software and Stata software.
ResultsStudies related to diagnosis, staging and prognosis: 42 articles in total were finally included after deducting repeats. The pooled sensitively of FDG-PET/CT in diagnosis pancreatic cancer, evaluating lymph node metastasis and distant metastasis were 0.93 (95%CI: 0.92-0.94), 0.65 (95%CI: 0.56-0.74) and 0.82 (95%CI: 0.71-0.90), respectively; and the corresponding specificity was 0.73 (95%CI: 0.70-0.76), 0.86 (95%CI: 0.79-0.91) and 0.95 (95%CI: 0.91-0.98), respectively. In prognosis analysis, significant difference of overall survival (HRpooled=1.96, 95%CI: 1.52-2.52) and progress free survival (HRpooled=2.26, 95%CI: 1.33-3.83) were both observed between high and low standardized uptake value groups.
ConclusionFDG-PET/CT can be used as a valuable tool for diagnosis and prediction of overall survival for pancreatic cancer; however, the effect in the staging of pancreatic cancer was still indeterminate and to be further researched.
-
Key words:
- FDG-PET/CT /
- Pancreatic Cancer /
- Diagnosis /
- Staging /
- Prognosis /
- Meta-analysis
-
-
表 1 36篇被纳入的FDG-PET/CT对胰腺癌诊断性研究的文献特征
Table 1 Characteristics of 36 included studies for FDG-PET/CT in diagnositic pancreatic cancer
表 2 7篇被纳入的FDG-PET/CT对胰腺癌淋巴结和远期转移研究的文献特征
Table 2 Characteristics of 5 included studies for FDG-PET/CT in lymph node metastasis and distant metastasis of pancreatic cancer
表 3 5篇被纳入FDG-PET/CT对胰腺癌预后预测研究的文献特征
Table 3 Characteristic of 5 included studies for FDG-PET/CT in prognosis of pancreatic cancer
表 4 FDG-PET/CT对胰腺癌诊断及分期的Meta分析
Table 4 Meta-analysis of FDG-PET/CT in diagnosis and staging of pancreatic cancer
-
[1] Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2): 87-108.
[2] Hidalgo M. Pancreatic cancer[J]. N Engl J Med, 2010, 363(3): 298.
[3] Lemke AJ, Niehues SM, Hosten N, et al. Retrospective digital image fusion of multidetector CT and 18F-FDG PET: clinical value in pancreatic lesions-a prospective study with 104 patients[J]. J Nucl Med, 2004, 45(8): 1279-86.
[4] Heinrich S, Goerres GW, Schafer M, et al. Positron emission tomography/computed tomography influences on the management of resectable pancreatic cancer and its cost-effectiveness[J]. Ann Surg, 2005, 242(2): 235-43. doi: 10.1097/01.sla.0000172095.97787.84
[5] Maemura K, Takao S, Shinchi H, et al. Role of positron emission tomography in decisions on treatment strategies for pancreatic cancer[J]. J Hepatobiliary Pancreat Surg, 2006, 13(5): 435-41. doi: 10.1007/s00534-006-1102-8
[6] 王中秋, 卢光明, 朱虹, 等.胰腺癌18F-脱氧葡萄PET/CT的影像表现及其诊断价值[J].医学研究生学报, 2006, 19(4): 359-61. http://www.cnki.com.cn/Article/CJFDTotal-JLYB200604019.htm Wang ZQ, Lu GM, Zhu H, et al. 18F-FDG PET/CT finding in pancreatic carcinoma and their diagnosis value[J]. Yi Xue Yan Jiu Sheng Xue Bao, 2006, 19(4): 359-61. http://www.cnki.com.cn/Article/CJFDTotal-JLYB200604019.htm
[7] 王欣, 于丽娟. 18F-FDG PET/CT综合分析法在胰腺癌诊断中的价值[J].中国医学影像技术, 2007, 23(11): 1709-12. Wang X, Yu LJ. 18F-FDG PET/CT in detection of pancreatic cancer: value of synthetic analysis interpretation[J]. Zhongguo Yi Xue Ying Xiang Ji Shu, 2007, 23(11): 1709-12.
[8] Farma JM, Santillan AA, Melis M, et al. PET/CT fusion scan enhances CT staging in patients with pancreatic neoplasms[J]. Ann Surg Oncol, 2008, 15(9): 2465-71. doi: 10.1245/s10434-008-9992-0
[9] Schick V, Franzius C, Beyna T, et al. Diagnostic impact of 18F-FDG PET-CT evaluating solid pancreatic lesions versus endosonography, endoscopic retrograde cholangio-pancreatography with intraductal ultrasonography and abdominal ultrasound[J]. Eur J Nucl Med Mol Imaging, 2008, 35(10): 1775-85. doi: 10.1007/s00259-008-0818-x
[10] Strobel K, Heinrich S, Bhure U, et al. Contrast-enhanced 18F-FDG PET/CT: 1-stop-shop imaging for assessing the resectability of pancreatic cancer[J]. J Nucl Med, 2008, 49(9): 1408-13. doi: 10.2967/jnumed.108.051466
[11] Kauhanen SP, Komar G, Seppanen MP, et al. A prospective diagnostic accuracy study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer[J]. Ann Surg, 2009, 250(6): 957-63. doi: 10.1097/SLA.0b013e3181b2fafa
[12] 隗功华, 孙晓光, 刘建军, 等. 18F-FDG PET/CT在胰腺癌诊断中的价值[J].中华核医学与分子影像杂志, 2009, 29(1): 23-6. Wei GH, Sun XG, Liu JJ, et al. The value of 18F-FDG PET/CT in diagnosis and treatment of pancreatic malignant tumor[J]. Zhonghua He Yi Xue Yu Fen Zi Ying Xiang Za Zhi, 2009, 29(1): 23-6.
[13] 池晓华, 王全师, 李贵平, 等. 18F-FDG PET/CT在胰腺癌的应用[J].中国临床医学影像杂志, 2010, 21(10): 738-40. Chi XH, Wang QS, Li GP, et al. 18F-FDG PET/CT in the diagnosis of pancreatic cancer[J]. Zhongguo Lin Chuang Yi Xue Ying Xiang Za Zhi, 2010, 21(10): 738-40.
[14] 王晓乙. 64HD PET-CT应用于胰腺癌诊断的临床研究[D]. 复旦大学, 2010. Wang XY. Clinical study of the utilization of 64HD PET-CT in the diagnosis of pancreatic cancer[D]. Fudan Da Xue, 2010.
[15] Buchs NC, Buhler L, Bucher P, et al. Value of contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography in detection and presurgical assessment of pancreatic cancer: a prospective study[J]. J Gastroenterol Hepatol, 2011, 26(4): 657-62. doi: 10.1111/j.1440-1746.2010.06525.x
[16] 关志伟, 王瑞民, 刘长滨, 等.胰腺外病变在18F-FDG PET/CT诊断胰腺癌中的价值[J].中国临床医学影像杂志, 2011, 22(5): 324-7. http://www.cnki.com.cn/Article/CJFDTotal-LYYX201105010.htm Guan ZW, Wang RM, Liu CB, et al. The value of extra-pancreatic lesions on 18F-FDG PET/CT in improving the diagnosis of pancreatic cancer[J]. Zhongguo Lin Chuang Yi Xue Ying Xiang Za Zhi, 2011, 22(5): 324-7. http://www.cnki.com.cn/Article/CJFDTotal-LYYX201105010.htm
[17] 肖勇, 李亦钊, 孙南, 等. 18F-FDG PET/CT显像在胰腺癌诊断中的价值[J].消化肿瘤杂志 (电子版), 2011, 3(4): 224-8. http://www.cnki.com.cn/Article/CJFDTotal-XHZL201104006.htm Xiao Y, Li YZ, Sun N, et al. Clinical value of 18F-FDG PET/CT in the diagnosis of pancreatic cancer[J]. Xiao Hua Zhong Liu Za Zhi (Dian Zi Ban), 2011, 3(4): 224-8. http://www.cnki.com.cn/Article/CJFDTotal-XHZL201104006.htm
[18] Beliao S, Ferreira A, Vierasu I, et al. MR imaging versus PET/CT for evaluation of pancreatic lesions[J]. Eur J Radiol, 2012, 81(10): 2527-32. doi: 10.1016/j.ejrad.2011.11.045
[19] 谷鑫金. 18F-FDG PET/CT在鉴别胰腺癌与慢性肿块型胰腺炎及胰腺癌术前评估中的应用[D]. 中国人民解放军医学院, 2012. Gu XJ. The application of 18F-FDG for differentiating pancreatic carcinoma from chronic mass-forming pancreatitis and in preoperative assessment of pancreatic carcinoma[D]. Zhongguo Ren Min Jie Fang Jun Yi Xue Yuan, 2012.
[20] Herrmann K, Erkan M, Dobritz M, et al. Comparison of 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography (FLT PET) and FDG PET/CT for the detection and characterization of pancreatic tumours[J]. Eur J Nucl Med Mol Imaging, 2012, 39(5): 846-51.
[21] Yao J, Gan G, Farlow D, et al. Impact of 18F-fluorodeoxyglycose positron emission tomography/computed tomography on the management of resectable pancreatic tumours[J]. ANZ J Surg, 2012, 82(3): 140-4. doi: 10.1111/ans.2012.82.issue-3
[22] 张雯杰. 18F-FDG PET-CT检查对胰腺癌的应用研究[D]. 北京协和医学院, 2012. Zhang WJ. Application of 18F-FDG PET-CT in pancreatic cancer[D]. Beijing Xie He Yi Xue Yuan, 2012.
[23] 方艺, 张建, 崔莹, 等.双时相18F-FDG PET/CT显像在胰腺良恶性病变鉴别诊断中的应用[J].医学影像学杂志, 2013, 23(11): 1733-5. Fang Y, Zhang J, Cui Y, et al. Value of dual-time-point 18F-FDG PET/CT in differential diagnose of pancreatic disease[J]. Yi Xue Ying Xiang Xue Za Zhi, 2013, 23(11): 1733-5.
[24] Hu SL, Yang ZY, Zhou ZR, et al. Role of SUV (max) obtained by 18F-FDG PET/CT in patients with a solitary pancreatic lesion: predicting malignant potential and proliferation[J]. Nucl Med Commun, 2013, 34(6): 533-9. doi: 10.1097/MNM.0b013e328360668a
[25] Nagamachi S, Nishii R, Wakamatsu H, et al. The usefulness of 18F-FDG PET/MRI fusion image in diagnosing pancreatic tumor: comparison with 18F-FDG PET/CT[J]. Ann Nucl Med, 2013, 27(6): 554-63. doi: 10.1007/s12149-013-0719-3
[26] 潘树波, 赵红川, 谢坤, 等.增强CT和PET/CT对胰腺癌诊断及分期中的价值[J].肝胆外科杂志, 2013, 21(6): 453-6. Pan SB, Zhao HC, Xie K, et al. The value of 18F-FDG PET/CT in primary diagnosis and staging of pancreatic cancer[J]. Gan Dan Wai Ke Za Zhi, 2013, 21(6): 453-6.
[27] Santhosh S, Mittal BR, Bhasin D, et al. Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the characterization of pancreatic masses: experience from tropics[J]. J Gastroenterol Hepatol, 2013, 28(2): 255-61. doi: 10.1111/jgh.2013.28.issue-2
[28] 余仲飞, 方艺, 张建, 等. 18F-FDG PET-CT与增强CT在胰腺病变良恶性鉴别及胰腺癌分期中的价值对比研究[J].医学影像学杂志, 2013, 23(8): 1236-40. http://www.cnki.com.cn/Article/CJFDTotal-XYXZ201308032.htm Yu ZF, Fang Y, Zhang J, et al. Comparative study of 18F-FDG PET/CT and contract CT in diagnosing and staging assessment of pancreatic canner[J]. Yi Xue Ying Xiang Xue Za Zhi, 2013, 23(8): 1236-40. http://www.cnki.com.cn/Article/CJFDTotal-XYXZ201308032.htm
[29] Ergul N, Gundogan C, Tozlu M, et al. Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in diagnosis and management of pancreatic cancer; comparison with multidetector row computed tomography, magnetic resonance imaging and endoscopic ultrasonography[J]. Rev Esp Med Nucl Imagen Mol, 2014, 33(3): 159-64.
[30] Hamidian Jahromi A, Fallahzadeh MK, Takalkar A, et al. Impact of Plasma Glucose Level at the Time of Fluorodeoxyglucose Administration on the Accuracy of FDG-PET/CT in the Diagnosis of Pancreatic Lesions[J]. Int J Endocrinol Metab, 2014, 12(4):e16429.
[31] 刘一, 李亚明, 李娜, 等. 18F-FDG PET/CT在胰腺良恶性病变的诊断及鉴别诊断中的价值[J].中国医科大学学报, 2014, 43(6): 547-52. Liu Y, Li YM, Li N, et al. Application of 18F-FDG PET/CT in the diagnosis and differential diagnosis of benign and malignant pancreatic lesions[J]. Zhongguo Yi Ke Da Xue Xue Bao, 2014, 43(6): 547-52.
[32] 王治国, 石庆学, 郭佳, 等. CA19-9、增强MRI和PET/CT在胰腺癌诊断及分期中的价值[J].标记免疫分析与临床, 2014, 21(5): 507-10. Wang ZG, Shi QX, Gui J, et al. Clinical Value of CA19-9, contrast-enhanced MRI and PET-CT in the diagnosis and staging of pancreatic cancer[J]. Biao Ji Mian Yi Fen Xi Yu Lin Chuang, 2014, 21(5): 507-10.
[33] 卞光荣, 陈丽, 王西珍, 等.血清CA19-9、CA125和PET/CT显像联合检测对胰腺癌的诊断价值[J].中国卫生检验杂志, 2015, 25(22): 3897-8. Bian GR, Chen L, Wang XZ, et al. Diagnostic value of combined measurement of serum CA19-9, CA125 with PET/CT scanning in patients with pancreatic cancer[J]. Zhongguo Wei Sheng Jian Yan Za Zhi, 2015, 25(22): 3897-8.
[34] 程兵. 18F-FDG与18F-FCH PET/CT在胰腺癌评估中的实验及临床研究[D]. 郑州大学, 2015. Cheng B. Application of 18F-FCH PET/CT in pancreatic cancer[D]. Zhengzhou Da Xue, 2015.
[35] Kauhanen S, Rinta-Kiikka I, Kemppainen J, et al. Accuracy of 18F-FDG PET/CT, Multidetector CT, and MR Imaging in the Diagnosis of Pancreatic Cysts: A Prospective Single-Center Study[J]. J Nucl Med, 2015, 56(8): 1163-8.
[36] 苏慧东. 18F-FDG PET-CT显像对胰腺癌的临床诊断价值[J].中国卫生标准管理, 2015, 6(22): 169-70. http://www.cnki.com.cn/Article/CJFDTotal-WSBZ201522130.htm Su HD. Clinical Diagnostic Value of PET-CT 18F-FDG Imaging in Pancreatic Cancer[J]. Zhongguo Wei Sheng Biao Zhun Guan Li, 2015, 6(22): 169-70. http://www.cnki.com.cn/Article/CJFDTotal-WSBZ201522130.htm
[37] 汤颖, 李诗运, 黎芬. 18F-FDG PET-CT显像对胰腺炎和胰腺癌的鉴别诊断[J].郑州大学学报 (医学版), 2015, 50(4): 572-4. Tang Y, Li SY, Li F. 18F-FDG PET/CT in the differential diagnosis of pancreatitis and pancreatic cancer[J]. Zhengzhou Da Xue Xue Bao (Yi Xue Ban), 2015, 50(4): 572-4.
[38] Zhang J, Zuo CJ, Jia NY, et al. Cross-modality PET/CT and contrast-enhanced CT imaging for pancreatic cancer[J]. World J Gastroenterol, 2015, 21(10): 2988-96.
[39] Imai H, DoiR, Kanazawa H, et al. Preoperative assessment of para-aortic lymph node metastasis in patients with pancreatic cancer[J]. Int J Clin Oncol, 2010, 15(3): 294-300.
[40] Hwang JP, Lim I, Chang KJ, et al. Prognostic value of SUVmax measured by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography in Patients with Pancreatic Cancer[J]. Nucl Med Mol Imaging, 2012, 46(3): 207-14. doi: 10.1007/s13139-012-0151-y
[41] Xu HX, Chen T, Wang WQ, et al. Metabolic tumour burden assessed by 18F-FDG PET/CT associated with serum CA19-9 predicts pancreatic cancer outcome after resection[J]. Eur J Nucl Med Mol Imaging, 2014, 41(6): 1093-102. doi: 10.1007/s00259-014-2688-8
[42] 李文新, 沙如拉, 包佳琪, 等.胰腺癌患者术前PET/CT对术后复发及预后预测价值分析[J].中华肿瘤防治杂志, 2015, 22(14): 1138-42. Li WX, Sha RL, Bao JQ, et al. Correlation and predictive value of preoperative 18F-FDG PET/CT for postoperative recurrence in patients with resectable pancreatic cancer[J]. Zhonghua Zhong Liu Fang Zhi Za Zhi, 2015, 22(14): 1138-42.
[43] Wang SL, Cao S, Sun YN, et al. Standardized uptake value on positron emission tomography/computed tomography predicts prognosis in patients with locally advanced pancreatic cancer[J]. Abdom Imaging, 2015, 40(8): 3117-21.
[44] Moon SY, Joo KR, So YR, et al. Predictive value of maximum standardized uptake value (SUVmax) on 18F-FDG PET/CT in patients with locally advanced or metastatic pancreatic cancer[J]. Clin Nucl Med, 2013, 38(10): 778-83.
[45] Wang Z, Chen JQ, Liu JL, et al. FDG-PET in diagnosis, staging and prognosis of pancreatic carcinoma: a Meta-analysis[J]. World J Gastroenterol, 2013, 19(29): 4808-17. doi: 10.3748/wjg.v19.i29.4808
[46] 蒋晓涵, 胡乃中, 魏明通. 18F-FDG PET与18F-FDG PET/CT在胰腺癌中诊断价值的Meta分析[J].世界华人消化杂志, 2016, 24(1): 136-46. Jiang XH, Hu NZ, Wei MT. Value of 18F-fluorodexygluose positron emission tomography and 18F-fluorodexygluose positron emission tomography/computed tomography in diagnosis of pancreatic cancer: A systemic review and meta-analysis[J]. Shi Jie Hua Ren Xiao Hua Za Zhi, 2016, 24(1): 136-46.
[47] Tang S, Huang G, Liu J, et al. Usefulness of 18F-FDG PET, combined FDG-PET/CT and EUS in diagnosing primary pancreatic carcinoma: a meta-analysis[J]. Eur J Radiol, 2011, 78(1): 142-50.