前列腺腺癌组织中HPV16/18蛋白的表达及意义

何娟; 黄林; 孙奇; 陆妹英; 范永毅

doi:10.3971/j.issn.1000-8578.2017.02.010

前列腺腺癌组织中HPV16/18蛋白的表达及意义

Expression and Significance of HPV16/18 Protein in Prostate Cancer Tissues

摘要

摘要:
目的探讨高危型人乳头瘤病毒16/18（HPV16/18）在人体前列腺腺癌组织中的表达及其与临床病理参数的关系。
方法选取86例前列腺腺癌和80例前列腺增生组织标本，通过免疫组织化学Max Vision二步法检测HPV16/18蛋白表达情况。
结果前列腺腺癌组和前列腺增生组的HPV16/18阳性表达率分别为22.58%和11.25%，差异有统计学意义（P=0.018）。在前列腺腺癌组内，HPV16/18的表达与Gleason评分和临床分期有一定的关系，差异有统计学意义（均P<0.05），而与患者PSA水平、有无脉管侵犯、有无淋巴结转移和有无远处转移关系不大，差异无统计学意义（均P>0.05）。
结论 HPV16/18与前列腺腺癌的发生发展有一定的关系，有可能成为前列腺腺癌早诊早治的生物学指标之一。

Abstract:
Objective To investigate the expression of HPV16/18 in human prostate cancer tissues and its relationship with clinicopathological parameters.
Methods The expressions of HPV16/18 were detected by immunohistochemistry in 86 cases of prostatic adenocarcinoma tissues and 80 cases of benign prostatic hyperplasia tissues.
Results The positive expression rates of HPV16/18 in the prostate cancer group and the benign prostatic hyperplasia group were 22.58% and 11.25%, respectively(P=0.018). In the prostate cancer group, there were certain relationship of HPV16/18 expression with Gleason score and clinical stage(all P<0.05), while no relationship with PSA levels, vascular invasion, lymph node metastasis or distant metastasis(all P>0.05).
Conclusion There is a certain relationship between HPV16/18 and the occurrence and development of prostate cancer, which may be one of the biological indicators for early diagnosis and treatment of prostate cancer.

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