Abstract: Lung cancer is the most common cancer and the leading cause of cancer death worldwide. microRNAs (miRNAs) are a wide class of highly conservative, endogenous, non-coding, short (21-24 nt) and single-stranded RNA molecules, which play an important role in gene regulation. miRNA-related single nucleotide polymorphisms mainly include SNPs in miRNA genes, SNPs in miRNA biogenesis genes and SNPs in miRNA-binding sites. miR-SNPs can make the miRNA regulation network abnormal and have been implicated in cancer development, by influencing the mature process and expression level of miRNAs, and the identification with miRNA target sites. This review focus on the recent advances of relationship between miRNA-related SNPs and lung cancer susceptibility, thus to provide references for further researches, prevention and control of cancers, especially for lung cancer.