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尿激酶型纤溶酶原激活物系统与急性髓细胞白血病关系的研究进展

廖君, 孔佩艳

廖君, 孔佩艳. 尿激酶型纤溶酶原激活物系统与急性髓细胞白血病关系的研究进展[J]. 肿瘤防治研究, 2016, 43(4): 305-308. DOI: 10.3971/j.issn.1000-8578.2016.04.014
引用本文: 廖君, 孔佩艳. 尿激酶型纤溶酶原激活物系统与急性髓细胞白血病关系的研究进展[J]. 肿瘤防治研究, 2016, 43(4): 305-308. DOI: 10.3971/j.issn.1000-8578.2016.04.014
LIAO Jun, KONG Peiyan. Research Progress of Relationship Between Urokinase Plasminogen Activator System and Acute Myelocytic Leukemia[J]. Cancer Research on Prevention and Treatment, 2016, 43(4): 305-308. DOI: 10.3971/j.issn.1000-8578.2016.04.014
Citation: LIAO Jun, KONG Peiyan. Research Progress of Relationship Between Urokinase Plasminogen Activator System and Acute Myelocytic Leukemia[J]. Cancer Research on Prevention and Treatment, 2016, 43(4): 305-308. DOI: 10.3971/j.issn.1000-8578.2016.04.014

尿激酶型纤溶酶原激活物系统与急性髓细胞白血病关系的研究进展

详细信息
    作者简介:

    廖君(1989-),女,硕士在读,主要从事难治性白血病的诊疗

  • 中图分类号: R733.71

Research Progress of Relationship Between Urokinase Plasminogen Activator System and Acute Myelocytic Leukemia

  • 摘要: 尿激酶型纤溶酶原激活物系统(urokinase plasminogen activator system, uPAs)在急性髓细胞白血病(acute myelocytic leukemia, AML)发生、发展过程中的作用已成为当前临床研究关注的热点。尿激酶型纤溶酶原激活物(uPA)与其受体(uPAR, 又称CD87)结合促使纤溶酶原激活为纤溶酶,这一过程受到uPAs的两种主要抑制剂纤维蛋白溶酶原激活物抑制物(plasminogen activator inhibitor, PAI)PAI-1和PAI-2的调控。激活的纤溶酶一方面导致细胞外基质及基底膜的降解,另一方面增加基质金属蛋白酶原(Pro-matrix metalloproteinases, Pro-MMP)及生长因子(growth factor, GF)的激活,促进AML细胞髓外浸润、转移及增殖。并且uPAs作为纤溶系统的重要成分之一,其表达的上调导致纤溶亢进,增加AML患者发生出血的风险。本文对uPAs的结构及其在AML发生发展和治疗中的作用进行综述。

     

    Abstract: Currently, the role of urokinase plasminogen activator system (uPAs) in the occurrence and development of acute myelocytic leukemia (AML) has become a hot topic in clinical researches. The association of uPA to its receptor triggers the conversion of plasminogen into plasmin. This process is regulated by the uPA inhibitors (PAI-1 and PAI-2). On one hand, the activated plasmin promotes the degradation of basement membrane and extracellular matrix (ECM) components; on the other hand, it could activate ECM pro-matrix metalloproteinases (Pro-MMP) and growth factor (GF), thus contributing to the leukaemic cells extramedullary disseminations, metastasizing and proliferation. What's more, as one of the main components of fibrinolytic system, uPAs over-expression is associated with hyperfibrinolysis, leading to increased bleeding complications. This paper mainly summarizes the structure of uPAs and its contribution to the occurrence, development as well as treatment of AML.

     

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出版历程
  • 收稿日期:  2015-08-03
  • 修回日期:  2015-11-23
  • 刊出日期:  2016-04-24

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