Abstract: It is increasingly recognized that low levels of serum vitamin D₃(VD₃) are associated with a greater risk of colorectal cancer(CRC). The majority of observational studies supported that serum 25-(OH)-VD₃ concentration has inverse relationships with the risk of CRC. However, whether oral vitamin D₃ intake or supplemental vitamin D₃ in diet could improve CRC patients' survival remains controversial. This review will summarize the recent findings about the relationship between VD₃ and CRC, and more and more prospectively basic research, clinical trials and population studies will be needed to clarify that whether VD₃ owns a value in CRC prevention and treatment.