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雌激素受体亚型ER-α36与乳腺癌关系的研究进展

李广亮, 滕理送

李广亮, 滕理送. 雌激素受体亚型ER-α36与乳腺癌关系的研究进展[J]. 肿瘤防治研究, 2016, 43(3): 238-242. DOI: 10.3971/j.issn.1000-8578.2016.03.015
引用本文: 李广亮, 滕理送. 雌激素受体亚型ER-α36与乳腺癌关系的研究进展[J]. 肿瘤防治研究, 2016, 43(3): 238-242. DOI: 10.3971/j.issn.1000-8578.2016.03.015
LI Guangliang, TENG Lisong. Progress of Relationship Between Estrogen Receptor (ER)-α36 and Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2016, 43(3): 238-242. DOI: 10.3971/j.issn.1000-8578.2016.03.015
Citation: LI Guangliang, TENG Lisong. Progress of Relationship Between Estrogen Receptor (ER)-α36 and Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2016, 43(3): 238-242. DOI: 10.3971/j.issn.1000-8578.2016.03.015

雌激素受体亚型ER-α36与乳腺癌关系的研究进展

详细信息
    作者简介:

    李广亮(1988-),男,博士,医师,主要从事乳腺癌的研究

    通讯作者:

    滕理送,E-mail: lsteng@zju.edu.cn

  • 中图分类号: R737.9

Progress of Relationship Between Estrogen Receptor (ER)-α36 and Breast Cancer

  • 摘要: 雌激素受体(estrogen receptor, ER)是一类有配体激活的核转录因子,介导大部分的雌激素反应,在体内具有重要的生理功能效应。ER主要分为ER-α和ER-β两个亚型,其中ER-α主要表达于乳腺和子宫组织内,在乳腺癌发生发展过程中发挥重要调控作用。ER-α36是ER-α的一个分子量大小为36kD的新亚型,缺少ER-α的转录活化结构域AF-1及AF-2。ER-α36主要表达于乳腺癌细胞的细胞膜与胞质中,介导非核途径的雌激素信号转导。目前的研究认为ER-α36的调节异常与乳腺癌的发生、发展及治疗疗效密切相关,其有可能成为一个新的乳腺癌诊断、治疗及预后的标志物。在此,本文将对ER-α36的生物特性与功能、及其在乳腺癌内分泌耐药中的作用机制作一综述,评价其潜在的临床应用价值。

     

    Abstract: Estrogen receptor (ER) are a class of ligand-activated nuclear transcription factor, mediating most of the estrogen signals and play an important role in physiological function in vivo. There are two ER subtypes: ER-α and ER-β. ER-α is mainly expressed in breast and uterine tissues, which has an important role in the development and progression of breast cancer. ER-α36 is a new variant of ER-α, with a molecular weight of 36 kD. It lacks both transactivation domains (activation function 1 and activation function 2) of the classical ER-α. It is predominantly located on the plasma membrane and in the cytoplasm, and modulates nongenomic estrogen signaling. Recent studies found that the dysregulation of ER-α36 is closely associated with carcinogenesis, aggressiveness and therapeutic response of breast cancer, suggesting that ER-α36 may be a novel biomarker of great value for the diagnosis, prognosis, and treatment of breast cancer. In this review, we will overview and update the biological nature and function of ER-α36, and the potential mechanism by which ER-α36 may play an important role in the development of breast cancer resistance to endocrine therapies.

     

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出版历程
  • 收稿日期:  2015-07-20
  • 修回日期:  2015-12-20
  • 刊出日期:  2016-03-24

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