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长链非编码RNA与宫颈癌的相关性研究进展

Association Between Long Non-coding RNA and Cervical Cancer

  • 摘要: 宫颈癌的发病率和死亡率均位于女性肿瘤的第二位,早期诊断与治疗是降低其死亡率的有效途径。长链非编码RNA(long non-coding RNA, lncRNA)是一类长度大于200 nt且缺乏编码蛋白能力的RNA,其通过多种途径参与基因的表达调控,在个体正常发育和疾病发生中起着重要作用。越来越多的研究表明lncRNA与肿瘤的发生、发展密切相关。本文将对lncRNAs在宫颈癌中的作用及其分子机制进行综述。

     

    Abstract: The inciderce and mortality of cervical cancer are on the second of female cancer, and early detection with treatment is an effective way to reduce its mortality. Long non-coding RNA(lncRNA)is a group of non-protein coding regulatory RNAs with a length of longer than 200 nucleotides, and plays an important role in various processes of individual development and diseases progression through regulating gene expression in different mechanism. Many studies indicated that lncRNAs are involved in numerous biological processes including the etiology and progression of cancers. This paper provides an overview on the molecular processes affected by lncRNAs in cervical cancer.

     

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