Abstract: Objective To analyze the trends on the morbidity of nasopharyngeal carcinoma(NPC) among residents in Pudong New Area of Shanghai to offer the reference to the prevention and treatment of NPC. Methods The residents of Pudong New Area in Shanghai were recruited in this investigation from 2002 to 2013. The morbidities of NPC were calculated and these rates were standardized by the world population in 1985. The trends of NPC from 2002 to 2013 and annual percent changes(APC) were analyzed by Joinpoint regression program. Results Among the 1254 NPC cases occurred between 2002 and 2013, the rude incidence rate was 3.97 per 100 000 person-year, and the world age-standardized rate (ASR) of incidence was 2.29 per 100 000 person-year, and the gender ratio of male vs. female was 2.63:1. The total morbidity had a significant downward trend(APC=-5.89%, Z=4.77, P<0.001 ); the male rude incidence rate was 5.76 per 100 000 person-year, the world ASR of incidence was 3.36 per 100 000 person-year, and the male morbidity had a significant downward trend(APC=-6.19%, Z=4.73, P<0.001 ); the female rude incidence rate was 2.18 per 100 000 person-year, the world ASR of incidence was 1.25 per 100 000 person-year, and the female morbidity had a significant downward trend(APC=-5.56%, Z=3.87, P=0.003 ). The peak of incidence rate of the total was 65-69(11.52 per 100 000 person-year) years old, in male that was 70-74 years old(18.56 per 100 000 person-year) and in female that was 60-64 years old(6.17 per 100 000 person-year). Conclusion It is evident that the incidence of NPC have a significant downward trend in Pudong new area. Therefore, an increased focus on etiological study of NPC and early diagnosis technology application is also required to further control its incidence.