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脆性组氨酸三联体基因转录外显子丢失与肝细胞癌易感性的Meta分析

张成, 柯阳, 吴雪松, 施智甜, 谭宇棋, 王维, 黎建福, 王琳

张成, 柯阳, 吴雪松, 施智甜, 谭宇棋, 王维, 黎建福, 王琳. 脆性组氨酸三联体基因转录外显子丢失与肝细胞癌易感性的Meta分析[J]. 肿瘤防治研究, 2015, 42(11): 1124-1127. DOI: 10.3971/j.issn.1000-8578.2015.11.014
引用本文: 张成, 柯阳, 吴雪松, 施智甜, 谭宇棋, 王维, 黎建福, 王琳. 脆性组氨酸三联体基因转录外显子丢失与肝细胞癌易感性的Meta分析[J]. 肿瘤防治研究, 2015, 42(11): 1124-1127. DOI: 10.3971/j.issn.1000-8578.2015.11.014
ZHANG Cheng, KE Yang, WU Xuesong, SHI Zhitian, TAN Yuqi, WANG Wei, LI Jianfu, WANG Lin. Relationship Between Fragile Histidine Trial Gene Exon Loss and Susceptibility of Hepatocellular Carcinoma: A Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2015, 42(11): 1124-1127. DOI: 10.3971/j.issn.1000-8578.2015.11.014
Citation: ZHANG Cheng, KE Yang, WU Xuesong, SHI Zhitian, TAN Yuqi, WANG Wei, LI Jianfu, WANG Lin. Relationship Between Fragile Histidine Trial Gene Exon Loss and Susceptibility of Hepatocellular Carcinoma: A Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2015, 42(11): 1124-1127. DOI: 10.3971/j.issn.1000-8578.2015.11.014

脆性组氨酸三联体基因转录外显子丢失与肝细胞癌易感性的Meta分析

基金项目: 国家自然科学基金(81060204,81360360);云南省卫生厅卫生系统学科带头人培养计划项目(D-201220)
详细信息
    作者简介:

    张成(1990-),男,硕士,主要从事肝胆胰脾外科疾病诊治和科研工作

    通讯作者:

    王琳,E-mail:wanglinghjt@hotmail.com

  • 中图分类号: R730.2; R735.7

Relationship Between Fragile Histidine Trial Gene Exon Loss and Susceptibility of Hepatocellular Carcinoma: A Meta-analysis

  • 摘要: 目的 探讨脆性组氨酸三联体(Fhit)基因外显子丢失与肝细胞癌(HCC)发病风险的关系。方法 检索PubMed、CNKI、万方等数据库,收集有关Fhit基因转录外显子丢失与HCC易感性的病例对照研究,并从纳入文献中提取数据进行Meta分析。结果 最终纳入7个研究,涉及肝炎病毒相关HCC162例,对照组170例包括癌旁肝硬化组织136例,正常肝组织34例。HCC组与对照组Fhit外显子丢失比较的OR=5.02(95%CI: 2.99~8.43,P<0.00001);亚组分析显示,HCC组与癌旁肝硬化组织组比较的OR=3.55(95%CI: 2.06~6.13,P<0.00001);癌旁肝硬化组织组与正常肝组织组比较的OR=8.23(95%CI: 1.47~45.94,P=0.02)。结论 Fhit基因转录过程中外显子丢失可能是HCC发生的危险因素;肝炎病毒可能作用于肝细胞Fhit基因脆性位点造成其转录过程中外显子丢失,引起肝细胞恶变。

     

    Abstract: Objective To investigate the relationship between Fhit gene exon loss and risk of hepatocellular carcinoma(HCC). Methods By searching PubMed, CNKI, Wanfang Database, et al, the case-control studies about the relationship between Fhit gene exon loss and the risk of HCC were chosen. Then the Meta-analysis was conducted using odd rate(OR) and 95% confidential interval(CI) to assess the strength of association. Results Seven studies were finally chosen, including 162 hepatitis virus-related HCC cases and 170 controls(136 tumor-adjacent cirrhosis and 34 normal liver tissues). The risk of Fhit gene exon loss was higher in the HCC group than that in the control group(OR=5.02, 95%CI: 2.99-8.43, P<0.00001). Subgroup analysis showed the risk of Fhit gene exon loss was higher in HCC tissues than that in tumor-adjacent cirrhosis tissues(OR=3.55, 95%CI: 2.06-6.13, P<0.00001); and it was also higher in tumor-adjacent cirrhosis tissues than that in normal liver tissues(OR=8.23, 95%CI: 1.47-45.94, P=0.02). Conclusion Fhit gene exon loss may be notably correlated with hepatocellular carcinoma, and HBV or HCV may play a role in the development of HCC through leading the Fhit gene exon loss.

     

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出版历程
  • 收稿日期:  2014-11-09
  • 修回日期:  2015-03-18
  • 刊出日期:  2015-11-24

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