Abstract: Objective To evaluate the outcomes of surgical treatment of giant cell tumors on distal radius. Methods Nineteen patients with giant cell tumors on distal radius who were followed up for at least 24 months were selected. Three patients with giant cell tumors on distal radius were treated with intralesional excision, and the other 16 were managed with en bloc resection and reconstruction with autogenous fibular head graft. Patients were followed up for recurrence and joint function．Results Patients were followed up for an average of 45 months. One of 3 patients who were treated with intralesional excision experienced local recurrence. No patient who were treated with en bloc resection experienced local recurrence or complications of infection and peripheral nerve injury. Bone nonunion was found in two patients after reconstruction with fibular head graft, and bone union was achieved after autogenous ilium graft．MSTS scoring of limb function after operation was 76％, and limb function scoring was not associated with gender, tumor location and Campanacci giant cell tumor imaging classification，while was associated with surgical approaches. Conclusion En bloc resection for treatment of patients with giant cell tumors on distal radius can decrease the local recurrence rate. Autogenous fibular head graft can be used for reconstruction of wrist joint．