Abstract: Objective To analyze the therapeutic effect and prognosis-related factors of the patients with stageⅢB adenocarcinoma of esophagogastric junction(AEG) treated by surgery. Methods We analyzed retrospectively the clinicopathologic data of 213 AEG patients treated in the Fourth Hospital of Hebei Medical University from March 2006 to February 2007. A 5-years follow-up was conducted for this cohort of patients. Survival analysis was performed by Kaplan-Meier method and survival rate was obtained by life table method. Multivariate analysis was applied using Cox proportional hazard model. Results Radical surgery was performed in 207 patients; enlargement surgery was done in 3 patients, whereas the palliative operation was taken in 3 cases. The overall 1-, 3- and 5-year survival rates of this cohort were 80.0%, 46.0% and 32.0% respectively. These factors as follows were shown to be related to patients' survival by univariate analysis: gender, surgical type, surgical margin and adjuvant chemotherapy. Multivariate analysis demonstrated that gender(P=0.016), surgical type(P=0.025), surgical margin (P=0.002) and adjuvant chemotherapy(P=0.001)were regarded as independent prognostic factors. Conclusion The prognosis of stageⅢB AEG patients remains poor. Gender, surgical type, surgical margin and adjuvant chemotherapy are regarded as independent prognostic factors. Comprehensive therapy remains vital to enhance the treatment efficacy.