Abstract: Objective To evaluate the clinical effect of bladder-sparing surgery combined with internal iliac artery chemotherapy on patients with invasive bladder cancer．Methods Fifty-one patients with invasive bladder cancer in Xuzhou Cancer Hospital from Feb., 2008 to Aug., 2013 were randomly divided into two groups. The Group A was treated with transurethral resection of bladder tumor plus internal lilac artery chemotherapy, while the Group B used the TUR-BT and chemotherapy. The bladder preservation rates, 5-year survival rates and the incidence of side effects in these patients were compared. Multivariate Cox regression method was used to analyze the influence factors on patients who received internal iliac artery chemotherapy. Results The 5-year survival rates of Group A and B were 56.5% and 53.2%, respectively(P=0.18); the bladder preservation rates were 78.9%(15/19) and 62.5%(20/32)(P=0.024). Compared with Group B, the complications in Group A was lower(P=0.036). Internal iliac artery chemotherapy was particularly fit for stage T2 and single invasive bladder cancer patients. Conclusion Compared with GCGemcitabine 1 000mg/m² （d1, 8）+ Cisplatin 30mg/m2(d1-3) chemotherapy, internal iliac artery chemotherapy has the advantages of higher bladder preservation rate and lower complications without influencing survival rate. The main factors affecting the internal iliac artery chemotherapy include clinical TNM stage, histological grade and number of tumors.