微小RNAs在良恶性胸腔积液中的研究进展

MicroRNAs Expression in Benign and Malignant Pleural Effusion

摘要: microRNAs(miRNAs）是长度为19~24 nt的非编码小RNA，可通过与其靶mRNA特异性结合导致mRNA降解或翻译抑制，从而负向调控基因表达。miRNAs参与包括细胞分化、增殖、凋亡等一系列重要细胞活动的调控。miRNAs的异常表达与人类肿瘤密切相关。miRNAs具有较强的稳定性，广泛存在人体组织、体液中。本文就miRNAs在胸腔积液中的研究进展作一综述，以期为良恶性胸腔积液的鉴别等提供新的概念及思路。

Abstract: MicroRNAs (miRNAs) are 19-24nt non-coding RNA molecules that negatively regulate gene expression by degrading messenger RNA (mRNA) or suppressing mRNA translation. miRNAs have been found to regulate a variety of cellular processes including cell differentiation, proliferation and apoptosis.The deregulation of miRNAs expression is closely associated with human tumor. miRNAs widely exist in human tissues and body fluids with relative stability. This article reviews the expression of miRNAs in pleural effusion to provide the new concept and thinking for distinguishing benign and malignant pleural effusion.