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骨桥蛋白预测早期非小细胞肺癌患者预后的意义

吕梦果, 颜次慧, 宋新苗, 曹水

吕梦果, 颜次慧, 宋新苗, 曹水. 骨桥蛋白预测早期非小细胞肺癌患者预后的意义[J]. 肿瘤防治研究, 2015, 42(04): 340-344. DOI: 10.3971/j.issn.1000-8578.2015.04.005
引用本文: 吕梦果, 颜次慧, 宋新苗, 曹水. 骨桥蛋白预测早期非小细胞肺癌患者预后的意义[J]. 肿瘤防治研究, 2015, 42(04): 340-344. DOI: 10.3971/j.issn.1000-8578.2015.04.005
LV Mengguo, YAN Cihui, SONG Xinmiao, CAO Shui. Osteopontin Predicts Prognosis of Early Stage Non-small Cell Lung Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 340-344. DOI: 10.3971/j.issn.1000-8578.2015.04.005
Citation: LV Mengguo, YAN Cihui, SONG Xinmiao, CAO Shui. Osteopontin Predicts Prognosis of Early Stage Non-small Cell Lung Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 340-344. DOI: 10.3971/j.issn.1000-8578.2015.04.005

骨桥蛋白预测早期非小细胞肺癌患者预后的意义

基金项目: 天津市应用基础与前沿技术研究计划(14JCQNJC111500);天津医科大学科学基金(2012KYM03);天津市肿瘤医院博士启动基金(B1204)
详细信息
    作者简介:

    吕梦果(1988-),女,硕士,主要从事肿瘤学及生物治疗学基础与临床研究

    通讯作者:

    曹水,E-mail:caoshui9999@163.com

  • 中图分类号: R734.2

Osteopontin Predicts Prognosis of Early Stage Non-small Cell Lung Cancer Patients

  • 摘要: 目的 探讨骨桥蛋白(osteopontin,OPN)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达和预后意义。方法 采用免疫组织化学法检测84例非小细胞肺癌组织中OPN表达情况,利用χ 2检验和Kaplan-Meier生存曲线分析OPN表达与临床病理相关因素及患者术后总生存时间(overall survival,OS)、无疾病生存时间(disease-free survival,DFS)的关系。结果 84例非小细胞肺癌组织中OPN阳性表达率为83.3%(70/84)。在早期患者中,OPN阴性表达组DFS和OS长于OPN阳性组(χ 2=9.722,P=0.019;χ 2=6.064,P=0.014)。而晚期患者OPN阴性表达组DFS和OS与阳性组间比较差异无统计学意义。结论 非小细胞肺癌组织中存在OPN表达,OPN可能成为预测早期NSCLC患者预后的参考指标。

     

    Abstract: Objective To investigate the expression of osteopontin (OPN) in non-small cell lung cancer (NSCLC) tissues and its relationship with the prognosis of patients. Methods Immunohistochemistry (IHC) was applied to detect OPN expression in 84 cases of NSCLC tissues. The relationship between OPN expression and clinicopathological factors, overall survival(OS), disease-free survival(DFS) of the patients were analyzed by Chi-square test and Kaplan-Meier survival curve. Results The expression of OPN was 83.3% (70/84) in 84 cases of NSCLC tissues. Moreover, for patients with tumor-node-metastasis (TNM) stage, OS and DFS in OPN negative group were significantly higher than those in OPN positive group (χ 2=9.722, P=0.019; χ 2=6.064, P=0.014), however, there was no significance between the expression of OPN and the prognosis of patients with advanced stage NSCLC. Conclusion OPN is commonly expressed in NSCLC tissues and could be a novel prognostic biomarker for early stage NSCLC patients.

     

  • [1] Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014 [J]. CA Cancer J Clin, 2014, 64(1): 9-29.
    [2] Chansky K, Sculier JP, Crowley JJ, et al. The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer[J]. J Thorac Oncol, 2009, 4( 7): 792-801.
    [3] Jin Y, Tong DY, Tang LY, et al. Expressions of Osteopontin (OPN), alphanubeta3 and Pim-1 Associated with Poor Prognosis in Nonsmall Cell Lung Cancer (NSCLC) [J]. Chin J Cancer Res, 2012, 24 (2): 103-8.
    [4] Hoffman PC, Mauer AM , Vokes EE. Lung cancer [J]. Lancet, 20 00, 355(9202): 479-85.
    [5] Gao W, Wang BC, Di JS, et al. COX regression analysis of the prognosis of Non-small Cell Lung Cancer [J]. Zhong Liu Yan Jiu Yu Lin Chuang, 2003, 15(2): 91-3. [高卫, 王宝成, 狄剑时, 等. 非小细胞肺癌预后因素的Cox回归分析[J]. 肿瘤研究与临床, 20 03, 15(2): 91-3.]
    [6] Bogenrieder T, Herlyn M. Axis of evil: molecular mechanisms of cancer metastasis [J]. Oncogene, 2003, 22(42): 6524-36.
    [7] Wai PY, Kuo PC. Osteopontin: regulation in tumor metastasis[J]. Cancer Metastasis Rev, 2008, 27(1): 103-18.
    [8] Zhang J, Takahashi K, Takahashi F, et al. Differential osteopontin expression in lung cancer[J]. Cancer Lett, 2001, 171(2): 215-22.
    [9] Senger DR, Wirth DF, Hynes RO. Transformed mammalian cells secrete specific proteins and phosphoproteins[J]. Cell, 1979, 16 (4): 885-93.
    [10] Rangaswami H, Bulbule A, Kundu GC. Osteopontin: role in signaling and cancer progression[J].Trends Cell Biol, 2006, 16(2): 79 -87.
    [11] Rudland PS, Platt-Higgins A, El-Tanani M, et al. Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer[J]. Cancer Res, 2002, 62(12): 3417-27.
    [12] Bramwell VH, Doig GS, Tuck AB, et al. Serial plasma osteopontin levels have prognostic value in metastatic breast cancer[J]. Clin Cancer Res, 2006, 12(11 Pt 1): 3337-43.
    [13] Hu Z, Lin D, Yuan J, et al. Overexpression of osteopontin is associated with more aggressive phenotypes in human non-small cell lung cancer[J]. Clin Cancer Res, 2005, 11(13): 4646-52.
    [14] Mack PC, Redman MW, Chansky K, et al. Lower osteopontin plasma levels are associated with superior outcomes in advanced non-small-cell lung cancer patients receiving platinum-based chemotherapy: SWOG Study S0003[J]. J Clin Oncol, 2008, 26 (29): 4771-6.
    [15] Shevde LA, Das S, Clark DW, et al. Osteopontin: an effector and an effect of tumor metastasis[J].Curr Mol Med, 2010, 10(1): 71 -81.
    [16] El-Tanani MK. Role of osteopontin in cellular signaling and metastatic phenotype[J]. Front. Biosci, 2008, 13: 4276-84.
    [17] Anborgh PH, Mutrie JC, Tuck AB, et al. Role of the metastasispromoting protein osteopontin in the tumour microenvironment [J] J Cell Mol Med, 2010, 14(8): 2037-44.
    [18] Johnston NI, Gunasekharan VK, Ravindranath A, et al. Osteopontin as a target for cancer therapy[J]. Front Biosci, 2008, 13 : 4361-72.
    [19] Weber GF. The cancer biomarker osteopontin: combination with other markers[J]. Cancer Genomics Proteomics, 2011, 8(6): 26 3-88.
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出版历程
  • 收稿日期:  2014-09-04
  • 修回日期:  2014-11-24
  • 刊出日期:  2015-04-24

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