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钙库操纵性钙内流在肿瘤转移过程中的作用

顾鹏, 阳东荣

顾鹏, 阳东荣. 钙库操纵性钙内流在肿瘤转移过程中的作用[J]. 肿瘤防治研究, 2014, 41(09): 1054-1056. DOI: 10.3971/j.issn.1000-8578.2014.09.021
引用本文: 顾鹏, 阳东荣. 钙库操纵性钙内流在肿瘤转移过程中的作用[J]. 肿瘤防治研究, 2014, 41(09): 1054-1056. DOI: 10.3971/j.issn.1000-8578.2014.09.021
GU Peng, YANG Dongrong. Effect of Store-operated Calcium Entry on Tumor Metastasis[J]. Cancer Research on Prevention and Treatment, 2014, 41(09): 1054-1056. DOI: 10.3971/j.issn.1000-8578.2014.09.021
Citation: GU Peng, YANG Dongrong. Effect of Store-operated Calcium Entry on Tumor Metastasis[J]. Cancer Research on Prevention and Treatment, 2014, 41(09): 1054-1056. DOI: 10.3971/j.issn.1000-8578.2014.09.021

钙库操纵性钙内流在肿瘤转移过程中的作用

详细信息
    作者简介:

    顾鹏(1988-),男,硕士在读,医师,主要从事泌尿系肿瘤的研究

    通讯作者:

    阳东荣,E-mail:doc_ydr@163.com

  • 中图分类号: R73-37

Effect of Store-operated Calcium Entry on Tumor Metastasis

  • 摘要: 转移是恶性肿瘤治疗困难的重要因素之一。肿瘤细胞中,钙库操纵性钙内流(SOCE)及其主要组成分子STIM1和Orai1参与包括细胞迁移、侵袭在内的多种生物学功能。本文重点对SOCE的分子构成、激活机制、及其在乳腺癌、宫颈癌和肝癌转移过程中作用的研究进行综述,并对其机制进行初步分析。

     

    Abstract: Currently, metastasis is one of the main obstacles for malignancy therapy. Store-operated calcium entry(SOCE) and its main constituent molecules STIM1 and Orai1 are involved in a variety of biological functions, including cell migration and invasion. We reviewed the molecular composition and activation mechanism of SOCE as well as its effects and related mechanism on the metastasis of breast, cervical and liver cancer.

     

  • [1] Christofori G. New signals from the invasive front[J]. Nature, 2006, 44 1(7092), 444-50.
    [2] Fidler IJ.The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited[J]. Nat Rev Cancer, 2003, 3(6):453-8.
    [3] Yang S, Huang XY. Ca2+ influx through L-type Ca2+ channels controls the trailing tail contraction in growth factor-induced fibroblast cell migration[J]. J Biol Chem, 2005, 280(29):27130-7.
    [4] Lewis RS. The molecular choreography of a store-operated calcium channel[J]. Nature, 2007, 446(7133):284-7.
    [5] Soboloff J,Rothberg BS,Madesh M,et al.STIM protein: dynamic calcium signal transducers[J].Nat Rev Mol Cell Biol,2012,13(9):549-65.
    [6] Roos J, DiGregorio PJ, Yeromin AV, et al. STIM1, an essential and conserved component of store-operated Ca2+ channel function[J]. J Cell Biol, 2005, 169(3):435-45.
    [7] Liou J, Kim ML, Heo WD, et al. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx[J]. Curr Biol, 2005, 15(13): 12 35-41.
    [8] Feske S. ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond[J]. Immunol Rev, 2009, 231(1):189-209.
    [9] Cahalan MD. STIMulating store-operated Ca2+ entry[J].Nat Cell Biol, 2009, 11(6):669-77.
    [10] Zhang SL, Yu Y, Roos J, et al. STIMl is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane[J]. Nature, 2005, 437(7060):902-5.
    [11] Penna A, Demuro A, Yeromin AV, et al. The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers[J]. Nature, 2008, 456(7218):116-20.
    [12] Wu MM, Buchanan J, Luik RM, et al.Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane[J]. J Cell Biol, 2006, 174(6):803-13.
    [13] Park CY, Hoover PJ, Mullins FM, et al. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1[J]. Cell, 2009, 136(5):876-90.
    [14] Luik RM, Wu MM, Buchanan J, et a1.The elementary unit of storeoperated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions[J]. J Cell Biol, 2006, 174(6):815-25.
    [15] Yang DR, Shan YX, Liu XL, et al. Effect of stromal interaction molecular 1 gene on proliferation and apoptosis of prostate cancer PC-3 cells[J]. Zhonghua Shi Yan Wai Ke Za Zhi, 20 11,28(12):2046-8. [阳东荣,单玉喜,刘晓龙,等.基质交联分子1对 前列腺癌PC-3细胞增殖及细胞凋亡的影响[J].中华实验外科杂 志,2011,28(12):2046-8.]
    [16] Li W,Zhang M,XuL,et al.The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1[J]. Exp Toxicol Pathol, 2013, 65(7-8):1073-81.
    [17] Li G,Zhang Z,Wang R,et al.Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest[J]. J Exp Clin Cancer Res, 2013, 32:20.
    [18] Yang S,Zhang JJ,Huang XY.Orai1 and STIM1 are critical for breast tumor cell migration and metastasis[J]. Cancer Cell, 2009, 15 (2):124-34.
    [19] Guo W, Giancotti FG. Integrin signalling during tumour progression[J]. Nat Rev Mol Cell Biol, 2004, 5(10):816-26.
    [20] Webb DJ, Donais K, Whitmore LA, et al.FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly[J]. Nat Cell Biol, 2004, 6(2):154-61.
    [21] HuJ,Qin K,Zhang Y,et al. Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells[J]. Biochem Biophys Res Commun, 2011, 411(4):786-91.
    [22] Chen YF,Chiu WT,Chen YT,et al. Calcium store sensor stromalinteraction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis[J]. Proc Natl Acad Sci U S A,2011,108(37):15225-30.
    [23] Lysechko TL, Cheung SM, Ostergaard HL. Regulation of the tyrosine kinase Pyk2 by calcium is through production of reactive oxygen species in cytotoxic T lympho-cytes[J]. J Biol Chem, 2010, 28 5(41):31174-84.
    [24] Llovet JM, Ricci S. Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma[J]. N Engl J Med, 2008, 359(4):378-90.
    [25] Yang N,Tang Y,Wang F,et al. Blockade of store-operated Ca(2+) entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover[J]. Cancer Lett, 2013, 33 0(2):163-9.
    [26] Hauck CR, Hsia DA, Schlaepfer DD. The focal adhesion kinase-a regulator of cell migration and invasion[J]. IUBMB Life, 2002, 53 (2):115-9.
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出版历程
  • 刊出日期:  2014-09-24

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