Abstract: Siva1 is an alternative splice form of the protein encoded by apoptosis-inducing factor Siva. Siva1 can not only bind to and interact with a variety of receptors, such as CD27, BCL-2 or Bcl-xL, c-Abl, LPA2 receptor, but also can promote cell apoptosis by regulating ARF-MDM2-p53 pathway, inhibiting the activity of NF-κB and tyrosine phosphorylation, and also can suppress epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting the activity of microtubule destabilizing protein Stathmin and stabilizing microtubules. In addition, Siva1 can be used as a synergistic agent of cisplatin chemotherapy for patients with tumor. Nowadays, with the increasing morbidity, malignant tumor has seriously harmed human health. The molecular mechanism of Siva1 is very important to provide new methods and application prospects for tumor targeted therapy. Therefore, this paper reviews domestic and overseas research progresses of Siva1.