[1] |
Dinulescu DM, Ince TA, Quade BJ, et al. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer[J]. Nat Med, 2005,11(1):63-70.
|
[2] |
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009[J]. CA Cancer J Clin, 2009,59(4):225-49.
|
[3] |
Lee MY, Sun L, Veltmaat JM. Hedgehog and Gli signaling in embryonic mammary gland development[J]. J Mammary Gland Biol Neoplasia, 2013, 18(2):133-8.
|
[4] |
Kawabata N, Ijiri K, Ishidou Y, et al. Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth[J]. Int J Oncol, 2011,39(4):899-906.
|
[5] |
Katoh Y, Katoh M. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation[J]. Curr Mol Med, 2009, 9(7):873-86.
|
[6] |
Yauch RL, Dijkgraaf GJ, Alicke B, et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma[J]. Science, 2009, 326(5952):572-4.
|
[7] |
Yamasaki A, Kameda C, Xu R, et al. Nuclear factor kappaBactivated monocytes contribute to pancreatic cancer progression through the production of Shh[J]. Cancer Immunol Immunother, 20 10,59(5):675-86.
|
[8] |
Tang SN, Fu J, Nall D, et al. Inhibition of sonic hedgehogpathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics[J]. Int J Cancer, 20 11,131(1):30-40.
|
[9] |
Merchant AA, Matsui W. Targeting Hedgehog--a cancer stem cell pathway[J]. Clin Cancer Res, 2010, 16(12):3130-40.
|
[10] |
Singh BN, Fu J, Srivastava RK, et al. Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms[J]. PLoS One, 20 11, 6(11):e27306.
|
[11] |
Varnat F, Duquet A, Malerba M, et al. Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion[J]. EMBO Mol Med, 2009, 1(6-7):338-51.
|
[12] |
Bar EE, Chaudhry A, Lin A, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma[J]. Stem Cells, 2007, 25(10):2524-33.
|
[13] |
Zhao C, Chen A, Jamieson CH, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia[J]. Nature, 2009, 458(7239):776-9.
|
[14] |
Bailey JM, Singh PK, Hollingsworth MA. Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins[J]. J Cell Biochem, 2007, 10 2(4):829-39.
|
[15] |
Souzaki M,Kubo M,Kai M,et al.Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer[J]. Carcer Sci, 2011,102:373-81.
|
[16] |
Gonnissen A, Isebaert S, Haustermans K. Hedgehog signaling in prostate cancer and its therapeutic implication[J]. Int J Mol Sci, 20 13,14(7):13979-4007.
|
[17] |
Yan R,Peng X, Yuan X, et al. Suppression of growth and migration by blocking the Hedgehog signaling pathway in gastric cancer cells[J]. Cell Oncol (Dordr), 2013, 36(5):421-35.
|
[18] |
Onishi H, Kai M, Odate S, et al. Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer[J]. Cancer Sci, 2011, 10 2(6):1144-50.
|
[19] |
Cooper MK, Porter JA, Young KE, et al. Teratogen-mediated inhibition of target tissue response to Shh signaling[J]. Science, 19 98, 280(5369):1603-7.
|
[20] |
Lauth M, Bergström A,Shimokawa T, Toftgard R. Inhibition of GLI-mediated transcription and tumor cell growth by smallmolecule antagonists[J]. Proc Natl Acad Sci U S A, 2007, 10 4(20):8455-60.
|
[21] |
Kiselyov AS. Targeting the hedgehog signaling pathway with small molecules[J]. Anticancer Agents Med Chem, 2006, 6(5):445-9.
|
[22] |
Burgos-Ojeda D, Rueda BR, Buckanovich RJ. Ovarian cancer stem cell markers: prognostic and therapeutic implications[J]. Cancer Lett, 2012,322(1):1-7.
|
[23] |
Ray A, Meng E, Reed E, et al. Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells[J]. Int J Oncol, 2011, 39(4):797-804.
|
[24] |
Wu C,Cipollone J,Maines-Bandiera S,et al.The morphogenic function of E-Cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression differentiation research in biological diversity[J].2008,26:193-205.
|
[25] |
Chen X, Horiuchi A, Kikuchi N, et al. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis[J]. Cancer Sci, 2007, 98(1):68-76.
|
[26] |
Bhattacharya R, Kwon J, Ali B, et al. Role of hedgehog signaling in ovarian cancer[J]. Clin Cancer Res, 2008, 14(23):7659-66.
|
[27] |
Liao X, Siu MK, Au CW, et al. Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation[J]. Carcinogenesis, 2009, 30 (1):131-40.
|
[28] |
Yang L, He J, Huang S, et al. Activation of hedgehog signaling is not a frequent event in ovarian cancers[J]. Mol Cancer, 2009, 8: 112.
|
[29] |
Schmid S, Bieber M, Zhang F, et al. Wnt and hedgehog gene pathway expression in serous ovarian cancer[J]. Int J Gynecol Cancer, 2011, 21(6):975-80.
|
[30] |
McCann CK, Growdon WB, Kulkarni-Datar K, et al. Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model[J]. PLoS One, 2011, 6(11):e28077.
|
[31] |
Chen Y, Bieber MM, Teng NN. Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer[J]. Mol Carcinog,2013,2:232-7.
|