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卵巢癌治疗新靶标:Hedgehog信号通道

陈琦, 高国兰

陈琦, 高国兰. 卵巢癌治疗新靶标:Hedgehog信号通道[J]. 肿瘤防治研究, 2014, 41(08): 948-952. DOI: 10.3971/j.issn.1000-8578.2014.08.021
引用本文: 陈琦, 高国兰. 卵巢癌治疗新靶标:Hedgehog信号通道[J]. 肿瘤防治研究, 2014, 41(08): 948-952. DOI: 10.3971/j.issn.1000-8578.2014.08.021
CHEN Qi, GAO Guolan. Hedgehog Signaling Pathway in Targeted Therapy for Ovarian Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 948-952. DOI: 10.3971/j.issn.1000-8578.2014.08.021
Citation: CHEN Qi, GAO Guolan. Hedgehog Signaling Pathway in Targeted Therapy for Ovarian Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 948-952. DOI: 10.3971/j.issn.1000-8578.2014.08.021

卵巢癌治疗新靶标:Hedgehog信号通道

基金项目: 江西省自然科学基金资助项目 ( 20122BAB205053)
详细信息
    作者简介:

    陈琦(1974-),女,博士,主任医师,主要从事妇科肿瘤的研究

    通讯作者:

    高国兰,E-mail: chenqiyangbai@126.com

  • 中图分类号: R737.31

Hedgehog Signaling Pathway in Targeted Therapy for Ovarian Cancer

  • 摘要: 上皮性卵巢癌是卵巢恶性疾病中最常见的类型。在美国,卵巢癌是最致命的妇科恶性疾病。到目前为止,即使采取彻底的卵巢肿瘤细胞减灭术配合有效的术后化疗,临床预后仍然不尽人意。近来,我们逐渐认识到,在许多情况下,调控不同组织发育过程的细胞信号通道及信号分子是相类似的。当调控机制紊乱时,这些信号通道及信号分子将促使各种肿瘤形成及癌症发生。在这里,我们将讨论Hedgehog信号通道与卵巢正常生物学及癌症发生的相关性。通过一些体内外实验,我们已经逐步探索出Hedgehog信号通道促使卵巢形成及生长的分子机制。基于近年的研究成果,我们推断Hedgehog信号的抑制可以干预卵巢癌球样结构的形成。该信号通道的信号分子可能将成为一系列重要的药物治疗靶标,成为晚期卵巢癌重要的联合治疗方案的战略选择。

     

    Abstract: Epithelial ovarian carcinoma (EOC) is the most frequent type of ovarian malignancies and the most lethal gynecologic malignancy in the United States. To date, in spite of though ovarian cytoreductive surgery combined with effectively postoperative chemotherapy, the prognosis has remained unsatisfied. Recently, it has become increasingly clear that in many instances, the signaling pathway and molecule that regulate the development of different tissues are the same. When inappropriately regulated, these signal pathway and molecules would promote tumorigenesis and carcinogenesis. In this review, we will discuss the possible involvement of hedgehog(Hh) signaling pathway in the normal biology and carcinogenesis development in the ovary. The assays in vitro and in vivo have assisted the process of exploring the mechanisms of Hhdriven formation and growth of ovarian cancer. Based on recent studies, we conclude that the inhibition of Hh signaling pathway may interfere with proliferation of ovarian cancer cells and tumor growth in vivo. The molecules of the Hh signaling pathway may provide a serial of drug targets, which could be implemented into the crucial combined strategies for the treatment of ovarian cancer.

     

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出版历程
  • 刊出日期:  2014-08-24

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