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食管癌信号转导通路的改变

张娟, 刘康栋, 郭立华, 董子明

张娟, 刘康栋, 郭立华, 董子明. 食管癌信号转导通路的改变[J]. 肿瘤防治研究, 2014, 41(08): 943-947. DOI: 10.3971/j.issn.1000-8578.2014.08.020
引用本文: 张娟, 刘康栋, 郭立华, 董子明. 食管癌信号转导通路的改变[J]. 肿瘤防治研究, 2014, 41(08): 943-947. DOI: 10.3971/j.issn.1000-8578.2014.08.020
ZHANG Juan, LIU Kangdong, GUO Lihua, DONG Ziming. Changes of Signal Transduction Pathways in Esophageal Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 943-947. DOI: 10.3971/j.issn.1000-8578.2014.08.020
Citation: ZHANG Juan, LIU Kangdong, GUO Lihua, DONG Ziming. Changes of Signal Transduction Pathways in Esophageal Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 943-947. DOI: 10.3971/j.issn.1000-8578.2014.08.020

食管癌信号转导通路的改变

基金项目: 河南省2010年重大公益科研项目(101100910800)
详细信息
    作者简介:

    张娟(1982-),女,硕士在读,主要从事食管癌化学预防的研究

    通讯作者:

    董子明, E-mail: dongzm@zzu.edu.cn

  • 中图分类号: R735.1

Changes of Signal Transduction Pathways in Esophageal Cancer

  • 摘要: 食管癌是危及人类健康的常见恶性肿瘤,据2012年肿瘤年度报告显示,我国食管癌发病及死亡率依然居高不下,手术结合放、化疗治疗效果欠佳。针对肿瘤信号转导通路的肿瘤靶向药物在肺癌、乳腺癌、前列腺癌等治疗中取得了瞩目的成果。故了解食管癌发生中信号转导通路的活化对开展食管癌化学治疗和预防十分重要。本文通过对近期食管癌研究中信号转导通路的活化进行综述,为食管癌开展化学预防和治疗提供信号通路的新进展及有研究前景的新分子靶点。

     

    Abstract: Esophageal cancer is one of malignant tumors which threaten human health. Although surgery combined with radiotherapy and chemotherapy has made progress in recent years, its morbidity and mortality are still high in China. The tumor targeted drugs in signal transduction pathway make conspicuous achievements in the treatment for lung cancer, breast cancer and prostatic cancer,etc. Therefore, investigating the signaling pathway related with esophageal carcinogenesis will benefit both chemotherapy and chemoprevention. This article will provide new signal pathway progress and target proteins by summarizing the findings on the activation of signal transduction pathway in esophageal cancer.

     

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出版历程
  • 刊出日期:  2014-08-24

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