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共刺激分子B7家族在食管癌中的研究进展

王珊, 王玲, 曹娜娜, 赵博, 单保恩

王珊, 王玲, 曹娜娜, 赵博, 单保恩. 共刺激分子B7家族在食管癌中的研究进展[J]. 肿瘤防治研究, 2014, 41(08): 939-942. DOI: 10.3971/j.issn.1000-8578.2014.08.019
引用本文: 王珊, 王玲, 曹娜娜, 赵博, 单保恩. 共刺激分子B7家族在食管癌中的研究进展[J]. 肿瘤防治研究, 2014, 41(08): 939-942. DOI: 10.3971/j.issn.1000-8578.2014.08.019
WANG Shan, WANG Ling, CAO Nana, ZHAO Bo, SHAN Baoen. Review of Costimulatory Molecule B7 Family and Its Role in Esophageal Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 939-942. DOI: 10.3971/j.issn.1000-8578.2014.08.019
Citation: WANG Shan, WANG Ling, CAO Nana, ZHAO Bo, SHAN Baoen. Review of Costimulatory Molecule B7 Family and Its Role in Esophageal Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(08): 939-942. DOI: 10.3971/j.issn.1000-8578.2014.08.019

共刺激分子B7家族在食管癌中的研究进展

基金项目: 国家自然资金面上项目(81173611);河北省高等学校科学研究青年基金项目(QN2014049);2013年省级重大医学科研课题(Zd2013045)
详细信息
    作者简介:

    王珊(1988-),女,硕士在读,主要从事肿瘤免疫方向的研究

    通讯作者:

    单保恩,E-mail: shanbaoen_1962@163.com

  • 中图分类号: R735.1

Review of Costimulatory Molecule B7 Family and Its Role in Esophageal Cancer

  • 摘要: 食管癌的发病率占全世界恶性肿瘤发病率的第九位,其发病具有明显的地区性。中国是食管癌的高发地区,尽管近年来食管癌外科诊疗措施不断提高,但总体的治疗效果仍不尽如人意。随着肿瘤免疫学研究的进展和对肿瘤认识的逐步深入,人们发现食管癌的发生、发展与患者机体免疫功能低下密切相关。如何激发机体抗肿瘤免疫反应,杀灭体内残余癌细胞,成为提高食管癌疗效、预防其复发转移的关键。肿瘤浸润性T细胞(tumor-infiltrating lymphocytes,TIL)是介导抗肿瘤免疫应答的主要效应细胞,在抗食管癌免疫中起非常重要的作用。但由于其表面的协同刺激分子表达异常,致使TIL经常被诱导成“无能”,甚至抑制肿瘤免疫应答的其他免疫细胞、协助肿瘤细胞逃避机体监视。因此,本文就共刺激分子B7家族在食管癌组织中的表达及其临床意义作一综述,以期为今后研发食管癌的免疫治疗策略提供实验依据和理论支持。

     

    Abstract: The incidence of esophageal cancer accounts for the ninth-highest of malignancy incidence in the world. Its prevalence and distributions are relative regionalism. China is a high-risk area of esophageal cancer. Although varieties of therapeutic strategies, including conventional surgery, chemotherapy, radiotherapy and immunotherapy, and combination of these therapies, have been improved in the treatment for esophageal cancer patients in recent decades, the overall treatment efficacy remains disappointing. With the development of tumor immunology and the gradually in-depth understanding of tumor, it was found that the occurrence and progression of esophageal cancer are closely related to the immune depressive function in patients. How to stimulate anti-tumor immune response and kill residual cancer cells in vivo becomes the key to enhance the treatment efficacy of esophageal cancer and prevent the recurrence and metastasis. Tumor-infiltrating T cells (TIL) are the main effector cells to mediate anti-tumor immune response and play a very important role in anti-esophageal immunity. However, abnormal expression of its surface costimulatory molecules often lead to the anergy of TIL, or even suppress other immune cells in tumor immune responses and then help tumor cells evade the immune surveillance. Therefore, this article reviews the expression and clinical significance of costimulatory molecules B7 family in esophageal cancer, in order to provide experimental evidence and theoretical support for future development of immunotherapy strategies for esophageal cancer .

     

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出版历程
  • 刊出日期:  2014-08-24

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