高级搜索

女性非小细胞肺癌患者预后影响因素分析

叶 超, 何 斐, 李晓玉, 蔡 琳

叶 超, 何 斐, 李晓玉, 蔡 琳. 女性非小细胞肺癌患者预后影响因素分析[J]. 肿瘤防治研究, 2014, 41(07): 771-776. DOI: 10.3971/j.issn.1000-8578.2014.07.018
引用本文: 叶 超, 何 斐, 李晓玉, 蔡 琳. 女性非小细胞肺癌患者预后影响因素分析[J]. 肿瘤防治研究, 2014, 41(07): 771-776. DOI: 10.3971/j.issn.1000-8578.2014.07.018
YE Chao, HE Fei, LI Xiaoyu, CAI Lin. Prognostic Factors for Female Non-small Cell Lung Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 771-776. DOI: 10.3971/j.issn.1000-8578.2014.07.018
Citation: YE Chao, HE Fei, LI Xiaoyu, CAI Lin. Prognostic Factors for Female Non-small Cell Lung Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 771-776. DOI: 10.3971/j.issn.1000-8578.2014.07.018

女性非小细胞肺癌患者预后影响因素分析

详细信息
    作者简介:

    叶超(1987-),男,硕士在读,主要从事肿瘤流行病学的研究

    通讯作者:

    蔡琳,E-mail: cailin_cn@hotmail.com

  • 中图分类号: R734.2

Prognostic Factors for Female Non-small Cell Lung Cancer Patients

  • 摘要: 目的 探讨女性非小细胞肺癌预后影响因素。方法 回顾性分析326例女性非小细胞肺癌患者的临床资料,随访生存期为2006年12月至2013年1月。采用Kaplan-Meier绘制生存曲线,Cox比例风险回归模型进行单因素和多因素分析。结果 女性肺腺癌、肺鳞癌的5年生存率分别为28.9%和19.3%(P<0.0001);N2、N1、N0的5年生存率分别为4.1%、23.8%和66.1%(P<0.0001);治疗前有、无胸腔积液者的5年生存率分别为6.8%和38.4%(P<0.0001)。结论 病理类型、N分期、治疗前胸腔积液是女性非小细胞肺癌患者的独立预后因素。

     

    Abstract: Objective To explore the prognostic factors for female non-small cell lung cancer (NSCLC) patients. Methods Clinical data of 326 cases of female NSCLC patients were retrospectively analyzed. Follow-up survival period was from December 2006 to January 2013. Kaplan-Meier was applied to plot survival curves. Univariate and multivariate effects were measured by Cox proportional hazard regression. Results Five-year survival rates of female adenocarcinoma and squamous carcinoma patients were 28.9% and 19.3%(P<0.0001), respectively. Five-year survival rates of N2, N1, N0 were 4.1%, 23.8% and 66.1%(P<0.0001), respectively. Five-year survival rates of patients with or without pleural effusion before treatment were 6.8% and 38.4% (P<0.0001), respectively. Conclusion Histological type, N stage and pleural effusion before treatment are the independent prognostic factors for female NSCLC patients.

     

  • [1] Zhou QH, Liu LX, Che GW. A randomized clinical trial of preoperative neoadjuvant chemotherapy followed by surgery in the treatment of stage Ⅲ[J]. Zhongguo Fei Ai , 2001, 4(4): 25 1-6.[周清华, 刘伦旭, 车国卫, 等. 术前新辅助化疗加外科手 术治疗Ⅲ期非小细胞肺癌的随机对照临床试验[J]. 中国肺癌, 20 01, 4(4): 251-6.]
    [2] Radzikowska E, Glaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases[J]. Ann Oncol, 2002, 13(7) : 1087-93.
    [3] Hsu LH, Chu NM, Liu CC, et al. Sex-associated differences in non-small cell lung cancer in the new era: is gender an independent prognostic factor[J]. Lung Cancer, 2009, 66(2): 26 2-7.
    [4] Wu XY, Zhang CM, Ge XP, et al. Investigation and analysis on the survival duration and influencing factors of primary lung cancer in the urban area of Beijing[J]. Beijing Yi Xue, 2009, 31(1): 20-3. [吴新悦, 张城敏, 葛秀平, 等. 北京市1272例原发性肺癌生存时 间及影响因素调查分析[J]. 北京医学,2009, 31(1): 20-3.]
    [5] O’Connell JP, Kris MG, Gralla RJ, et al. Frequency and prognostic importance of pretreatment clinical characteristics in patients with advanced non-small cell lung cancer treated with combination chemotherapy[J]. J Clin Oncol,1986,4(11):1604-14.
    [6] Wu MN, Wang YY, An PT, et al. Analysis of prognostic factors in 54 1 female patients with advanced non-small cell lung cancer[J]. Zhongguo Fei Ai Za Zhi, 2011, 14(3): 245-50. [吴梅娜, 王玉艳, 安彤同, 等. 541例女性晚期非小细胞肺癌患者的预后因素分析 [J] 中国肺癌杂志, 2011, 14(3): 245-50.]
    [7] Zhang CM, Zhu GD, Xiao YH, et al. Evaluation on quality of life in women lung cancer patients and analysis of affecting factor[J]. Lin Chuang Fei Ke Za Zhi, 2011, 16(1): 78-80. [张翠敏, 朱贵东, 肖永红. 女性肺癌患者生存质量评价及影响因素分析[J]. 临床 肺科杂志, 2011, 16(1): 78-80.]
    [8] Wei W, Hua D. Prognostic factors in patients with non-small cell lung cancer[J]. Xian Dai Zhong Liu Yi Xue, 2008, 16(9): 15 49-51.[魏巍, 华东. 非小细胞肺癌预后影响因素分析[J].现代 肿瘤医学, 2008, 16(9): 1549-51.]
    [9] Shi MX, Xu GZ, Gao J, et al. Sex effect on prognosis after lung cancer operation[J]. Xian Dai Zhong Liu Yi Xue, 2004, 12(1): 36 -7. [施民新, 许广照, 高俊, 等. 性别对肺癌术后预后的影响 [J] 现代肿瘤医学, 2004, 12(1): 36-7.]
    [10] Donington JS, Le QT, Wakelee HA. Lung cancer in women: exploring sex differences in susceptibility, biology, and therapeutic response[J]. Clin Lung Cancer, 2006, 8(1): 22-9.
    [11] Yang SL, Zhou XY, Pang J, et al. Gender-associated differences in clinical characteristics and prognosis of patients with primary lung cancer[J]. Sichuan Yi Xue, 2012, 33(7): 1304-6.[杨胜利, 周 雪宇, 庞洁, 等. 女性原发性肺癌临床和预后特征与男性差异的 分析[J] , 四川医学, 2012, 33(7): 1304-6.]
    [12] Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009[J]. CA Cancer J Clin, 2009, 59(4): 225-49.
    [13] Kiyohara C, Ohno Y. Sex differences in lung cancer susceptibility: a review[J]. Gend Med, 2010, 7(5): 381-401.
    [14] Radzikowska E, Glaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases[J]. Ann Oncol, 2002, 13(7): 1087-93.
    [15] Asamura H, Goya T, Koshiishi Y, et al. A Japanese Lung Cancer Registry study: prognosis of 13 010 resected lung cancers[J]. J Thorac Oncol, 2008, 3(1): 46-52.
    [16] Pe?alver JC, Padilla J, Jordá C, et al. Use of blood products in patients treated surgically for stage I non-small cell lung cancer[J]. Arch Bronconeumol, 2005, 41(9): 484-8.
    [17] Padilla J, Calvo V, Pe?alver JC, et al. Stage Ⅰ non-small cell lung cancer up to 3cm in diameter. Prognostic factors[J]. Arch Bronconeumol, 2004, 40(3): 110-3.
    [18] Nosotti M, Rebulla P, Riccardi D, et al. Correlation between perioperative blood transfusion and prognosis of patients subjected to surgery for stage Ⅰ lung cancer[J]. Chest, 2003, 12 4(1): 102-7.
    [19] Kim JS, Kim JW, Han J, et al. Cohypermethylation of p16 and FHIT promoters as a prognostic factor of recurrence in surgically resected stage I non-small cell lung cancer[J]. Cancer Res, 2006, 66 (8): 4049-54.
    [20] Chen QK, Ding JA, Gao W. Skip metastasis to mediastinal lymph nodes: clinical significance and prognosis in stage Ⅲ non-small cell lung cancer[J]. Zhonghua Jie He He Hu Xi Za Zhi, 2005, 28 (7): 472-4.[陈乾坤, 丁嘉安, 高文. Ⅲ期非小细胞肺癌纵隔淋 巴结跳跃式转移的临床意义[J]. 中华结核和呼吸杂志, 2005, 28 (7): 472-4.]
    [21] Liu SJ, Long HC, Que QW. Relationship between mediastinal lymph node metastasis and prognosis of lung cancer[J]. Hainan Yi Xue Yuan Xue Bao, 2010, 16(7): 884-6, 894.[刘泗军, 龙鸿川, 阙 奇伟. 肺癌纵隔淋巴结转移与预后的关系分析[J]. 海南医学院 学报, 2010, 16(7): 884-6, 894.]
计量
  • 文章访问数:  1520
  • HTML全文浏览量:  298
  • PDF下载量:  798
  • 被引次数: 0
出版历程
  • 刊出日期:  2014-07-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭