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前列腺癌患者血清中NY-ESO-1的表达及其与Gleason评分的相关性

谢 冲, 黄其伟, 唐群业, 王国民

谢 冲, 黄其伟, 唐群业, 王国民. 前列腺癌患者血清中NY-ESO-1的表达及其与Gleason评分的相关性[J]. 肿瘤防治研究, 2014, 41(02): 111-113. DOI: 10.3971/j.issn.1000-8578.2014.02.004
引用本文: 谢 冲, 黄其伟, 唐群业, 王国民. 前列腺癌患者血清中NY-ESO-1的表达及其与Gleason评分的相关性[J]. 肿瘤防治研究, 2014, 41(02): 111-113. DOI: 10.3971/j.issn.1000-8578.2014.02.004
XIE Chong, HUANG Qiwei, TANG Qunye, WANG Guomin. Expression of NY-ESO-1 in Serum of Prostate Cancer Patients and Its Relationship with Gleason Score[J]. Cancer Research on Prevention and Treatment, 2014, 41(02): 111-113. DOI: 10.3971/j.issn.1000-8578.2014.02.004
Citation: XIE Chong, HUANG Qiwei, TANG Qunye, WANG Guomin. Expression of NY-ESO-1 in Serum of Prostate Cancer Patients and Its Relationship with Gleason Score[J]. Cancer Research on Prevention and Treatment, 2014, 41(02): 111-113. DOI: 10.3971/j.issn.1000-8578.2014.02.004

前列腺癌患者血清中NY-ESO-1的表达及其与Gleason评分的相关性

基金项目: 国家985三期医学学科建设项目资助课题(985IIIYFX0101);国家自然科学基金青年基金资助课题(81302215)
详细信息
    作者简介:

    谢冲(1981-),男,博士,住院医师,主要从事前列腺癌及男性科疾病研究

    通讯作者:

    王国民,E-mail:wang.guomin@zs-hospital.sh.cn

  • 中图分类号: R737.25

Expression of NY-ESO-1 in Serum of Prostate Cancer Patients and Its Relationship with Gleason Score

  • 摘要: 目的 检测NY-ESO-1在前列腺癌患者血清中的表达情况,研究其与Gleason评分的相关性。方法 收集148例前列腺癌、124例良性前列腺增生(BPH)和175例健康人群血清,用ELISA法检测NYESO-1抗原的表达水平,确定正常值范围,计算NY-ESO-1抗原表达阳性率、特异性和敏感度。用Western blot方法对阳性血清进行验证,并用统计学方法分析其与Gleason评分的相关性。结果 NY-ESO-1抗原在前列腺癌和BPH患者血清中的阳性表达率分别为48.6%和9.6%,两组数据之间差异有统计学意义(P=0.021)。以BPH患者组为对照,NY-ESO-1检测前列腺癌的敏感度和特异性分别为82.3%和41.9%;其中,在PSA 4~10 ng/ml人群中NY-ESO-1检测前列腺癌的敏感度和特异性分别为44.0%和33.9%。Spearman 等级相关分析NY-ESO-1与Gleason评分呈正相关(r=0.872)。结论 NY-ESO-1抗原在我国前列腺癌患者血清中有较高表达,NY-ESO-1抗原的表达水平与Gleason评分之间呈正相关。

     

    Abstract: Objective To investigate the expression of NY-ESO-1 in serum of prostate cancer patients and its relationship with Gleason score. Methods A total of 447 patients, which included 148 prostate cancer patients, 124 BPH patients and 175 healthy donors were enrolled in this study. The expression of NY-ESO-1 was detected by ELISA to determine the range of its normal values, and calculate their positive expression, specificity and sensitivity. The positive serum was verifi ed by Western blot and its relationship with Gleason Score was analyzed by statistic methods. Results The positive expression of NY-ESO-1 in prostate cancer patients and BPH patients were 48.6% and 9.6%, with signifi cant difference(P=0.021). Compared with BPH patients, the specifi city and sensitivity of NY-ESO-1 in diagnosing prostate cancer were 82.3% and 41.9%,respectively. The specifi city and sensitivity were 44.0% and 33.9%,respectively, in those patients with PSA values between 4-10 ng/ml. Spearman correlation analysis showed NY-ESO-1 and Gleason score were positively correlated(r=0.872). Conclusion NY-ESO-1 is highly expressed in prostate cancer patients, and the expression is positively correlated with Gleason score.

     

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出版历程
  • 收稿日期:  2013-09-01
  • 修回日期:  2013-10-15
  • 刊出日期:  2014-02-24

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