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58例局限期食管小细胞癌治疗分析

潘东风, 顾 兵, 周方正, 蔡晓军, 陈 萍

潘东风, 顾 兵, 周方正, 蔡晓军, 陈 萍. 58例局限期食管小细胞癌治疗分析[J]. 肿瘤防治研究, 2013, 40(12): 1183-1186. DOI: 10.3971/j.issn.1000-8578.2013.12.017
引用本文: 潘东风, 顾 兵, 周方正, 蔡晓军, 陈 萍. 58例局限期食管小细胞癌治疗分析[J]. 肿瘤防治研究, 2013, 40(12): 1183-1186. DOI: 10.3971/j.issn.1000-8578.2013.12.017
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PAN Dongfeng, GU Bing, ZHOU Fangzheng, CAI Xiaojun, CHEN Ping. Clinic Therapy to Primary Esophageal Small Cell Carcinoma with Limited Disease[J]. Cancer Research on Prevention and Treatment, 2013, 40(12): 1183-1186. DOI: 10.3971/j.issn.1000-8578.2013.12.017
Citation: PAN Dongfeng, GU Bing, ZHOU Fangzheng, CAI Xiaojun, CHEN Ping. Clinic Therapy to Primary Esophageal Small Cell Carcinoma with Limited Disease[J]. Cancer Research on Prevention and Treatment, 2013, 40(12): 1183-1186. DOI: 10.3971/j.issn.1000-8578.2013.12.017
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58例局限期食管小细胞癌治疗分析

  • 1. 442000湖北十堰，湖北医药学院附属人民医院肿瘤科；2.丹江口市第一医院肿瘤科；3.随州中心医院肿瘤科

详细信息
    作者简介:

    潘东风（1974-），男，硕士，副主任医师，主要从事肿瘤综合治疗的研究

    通讯作者:

    陈萍，E-mail:zlk_cp@163.com

  • 中图分类号: R735.1

Clinic Therapy to Primary Esophageal Small Cell Carcinoma with Limited Disease

  • 1.Department of Oncology, Renmin Hospital, Hubei University of Medicine,Shiyan 442000,China; 2. Department of Oncology, Danjiangkou City First Hospital; 3. Department of Oncology, Suizhou City Central Hospital

摘要

    摘要
  • 摘要: 目的 探讨原发性食管小细胞癌的不同治疗方法的疗效。方法 回顾性分析58例局限期食管小细胞癌，其中手术联合化疗18例，序贯放化疗23例，同步放化疗17例，采用Kaplan-Meier及Log rank 法分析其生存时间，并探讨三种方法的失败原因。结果 手术联合术后化疗组中位生存期为15.2月，其1、2及3年生存率分别为66.7%、33.3%及16.7%；序贯放化疗组中位生存期为17.3月，其1、2及3年生存率分别为69.6%、39.1%及21.7%，与手术联合组比较差异无统计学意义；同步放化疗组中位生存期为25.8月，其1、2及3年生存率分别为82.4%、52.9%及35.3%，与手术联合化疗组及序贯放化疗组，同步放化疗组生存时间明显延长。失败的主要原因是远处转移和局部复发，其中手术联合术后化疗组有15例出现远处转移；序贯放化疗组中有18例出现远处转移，与手术联合化疗组比较差异无统计学意义(P>0.05)；同步放化疗组有9例出现远处转移，较手术联合化疗组及序贯放化疗组低，差异有统计学意义(P<0.05)。结论 对局限期原发食管小细胞癌同步放化疗疗效较好，治疗失败的主要原因是远处转移。

     

    Abstract: Objective To investigate the effect of different treatment to Primary esophageal small cell carcinoma. Methods Fifty-eight patients with limit disease(LD) primary esophageal small cell carcinoma were collected from several hospital from Jan. 2000 to Jan. 2010. Eighteen cases of the 58 patients were treated by surgery +postoperative chemotherapy, twenty-three cases by non-concurrent radio-chemotherapy, and seventeen cases by concurrent chemo-radiotherapy. The Kaplan-Meier and log-rank methods were used to estimate survival time. Results The median survival time of surgical combined with chemotherapy was 15.2months; the 1-,2- and 3-year survival rates were 66.7%,33.3%and 16.7% respectively ; the median survival time of non- concurrent chemo-radiotherapy was 17.3 months; the 1-, 2- and 3-year survival rates were 69.6%, 39.1% and 21.7% respectively; the median survival time of concurrent chemo-radiotherapy was 25.8 months; the 1-, 2- and 3-year survival rates were 82.4%, 59.2% and35.3% respectively. Distant metastases of the surgical combined with chemotherapy, non- concurrent chemo-radiotherapy and concurrent chem.-radioyherapy, were 15 cases, 15 cases and 9 cases respectively. The local recurrence of the surgical combined with chemotherapy was higher than that of concurrent chem-radiotherapy(10 cases vs. 4 cases). Conclusion Concurrent chemo-radiotherapy was effective treatment to limit disease (LD) primary esophageal small cell carcinoma, and the reason of recurrence was distant metastases.

     

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  • [1] Hosokawa A,Shimada Y，Matsumura Y，et al．Small cell carcinoma of the esophagus．Analysis of 14 cases and literature review[J]. Hepatogastroenterology，2005，52(66)：1738-41.
    [2] Liu FS,Liu TH.Clinical oncologic pathology[M].Beijing:Union Press of Beijing Medical University ?? Peking Union Medical College,1997:680-1. [刘复生，刘彤华．临床肿瘤病理学[M]． 北京：北京医科大学中国协和医科大学联合出版社，1997： 68 0-1.]
    [3] Mckeown F. Oat-cell carcinoma of the oesophagus[J]. J Pathol Bacteriol, 1952, 64(4)：889-91.
    [4] Ibrahim NB, Briggs JC, Corbishley CM．Extrapulmonary oat cell carcinoma[J]. Cancer, 1984, 54(8)：1645-61.
    [5] Chen SB, Yang JS, Yang WP,et al. Treatment and prognosis of limited disease primary small cell carcinoma of esophagus[J]. Dis Esophagus,2011,24(2):114-9.
    [6] Lv J, Liang J, Wang J ,et al.Primary small cell carcinoma of the esophagus[J]. J Thorac Oncol， 2008，3(12):1460-5.
    [7] Duan HB, Wu HY, Su XD,et al. Clinical analysis of 33 cases of primary esophageal small cell carcinoma[J]. Ai Zheng, 20 07,26(7):771-4.[段海波，吴海鹰，苏晓东，等.33例原发食 管小细胞癌的临床分析[J].癌症，2007，26(7)：771-4.]
    [8] Yau KK, Siu WT, Wong DC, et al．Non-operative management of small cell carcinoma of the esophagus[J]．Dis Esophagus, 20 07, 20(6)：487-90.
    [9] Nishimaki T, Auzuki T, Nakagawa S, et al．Tumor spread and outcome of treatment in primary esophagus small cell carcinoma[J]. J Surg Oncol, 1997, 64(2):130-4.
    [10] Kuo CH, Hsieh CC, Chan ML,et al.Small cell carcinoma of the esophagus: a report of 16 cases from a single institution and literature review[J]. Ann Thorac Surg, 2011, 91(2):373-8.
    [11] Ding J, Ji J, Zhu W,et al. A retrospective study of different treatments of limited-stage small-cell esophageal carcinoma and associated prognostic factor analysis[J]. Dis Esophagus, 20 13.[Epub ahead of print]
    [12] Zhang BH, Yang WJ, Zhao L ,et al.Surgical treatment and prognostic analysis of 109 patients with primary esophageal small cell carcinoma[J].Zhonghua Zhong Liu Za Zhi, 2012 ,34(9):698-702.[张百华，杨文静，赵亮，等.109例原发性食 管小细胞癌的外科治疗和预后分析[J].中华肿瘤杂志，2012， 34 (9):698-702.]
    [13] Raja S, Rice TW, Rajeswaran J,et al.Esophageal small-cell cancer: study of a rare disease[J]. Dis Esophagus, 2013. [Epub ahead of print]
    [14] Vos B, Rozema T, Miller RC,et al.Small cell carcinoma of the esophagus: a multicentre Rare Cancer Network study[J]. Dis Esophagus,2011,24(4):258-64.
    [15] Ku GY, Minsky BD, Rusch VW, et al. Small-cell carcinoma of the esophagus and gastroesophageal junction：review of the Memorial Sloan—Kettering experience[J].Ann Oncol,2008,19(3):533-7.
    [16] Kawamura N, Ogasawara N, Utsumi K,et al.Long-term survival and improved quality of life after chemoradiotherapy to treat esophageal small cell carcinoma: a report of two cases[J]. Hepatogastroenterology, 2011,58(110-111):1588-94?? [17] Nakajima Y, Zenda S, Minashi K,et al.Non-surgical approach to small cell carcinoma of the esophagus: does this rare disease have the same tumor behavior as SCLC? [J]. Int J Clin Oncol,2012,17(6):610-5.
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出版历程
  • 收稿日期:  2012-10-31
  • 修回日期:  2013-04-22
  • 刊出日期:  2013-12-24

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