Clinicopathologic Characteristics of 47 Cases of Cutaneous Melanoma
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摘要: 目的 探讨黑色素瘤的临床与病理学特征，免疫组织化学特点，提高其早期诊断率。方法 分析47例黑色素瘤患者的临床资料和病理特征，15例免疫组织化学表型。结果 本组患者男31 例，女16例，年龄16~83岁，平均年龄52岁。32例黑色素瘤均由病理组织学直接诊断，15例经免疫组织化学检查辅助确诊。结论 黑色素瘤具有黑色素细胞的某些临床和病理特点，早期诊断比较困难，常依赖于免疫组织化学技术，其中Vim和CEA、Ki-67和P53 、Bcl-2和P16具有重要鉴别诊断价值；HMB45和CyclinD1、MelanA和S-100、PCK和EMA具有重要诊断意义。Abstract: Objective To investigate clinicopathologic charactieristics, pathological classification and immunohistochemical features of melanoma. Methods Clinicopathologic data of 47 cases of melanoma in our hospital were collected and analyzed. The immumohistochemical staining of Vim, CEA, Ki-67, P53, Bcl-2, P16, HMB45, CyclinD1, MelanA, S-100, PCK and EMA were performed in 15 cases of the specimens. Results Forty-seven patients (31 males and 15 females), aged from 16 to 83 years (mean 52) were analysed. Thirty-two specimens were diagnosed as melanoma based on the pathological features directly, while the others according to the immumohistochemical staining results. Conclusion Melanoma, which shares some features of melanocyte, was difficult to diagnose in the early stage. The immunophenotypes,such as Vim, CEA, Ki-67, P53, Bcl-2 and P16 were helpful in differential diagnosis, whereas HMB45, CyclinD1, MelanA, S-100, PCK and EMA could reveal the charactieristics of this tumor and prompt pathological diagnosis.
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