Abstract: Objective To learn more about Malignant cancer death and trends in Cixian. Methods Malignant cancer death data were collected in accordance with the "Cancer registration guidebook" requirements using Cixian Cancer registries from 2003 to 2007. Cancer crude mortality, standardized rate and world-standardized rate indicators were analyzed. Results From 2003 to 2007, the average crudemortality rate was 201.98/100 000, China age-standardized mortality rate was 188.07/100 000, and World age-standardized mortality rate was 256.13/100 000, among which, male crude mortality rate was 248.03/100 000, China age-standardized mortality rate was 255.73/100 000, and World age-standardized mortality rate was 345.84/100 000, and female crude mortality rate was 153.94/100 000, China age-standardized mortality rate was 129.96/100 000, and World age-standardized mortality rate was 179.10/100 000. According to the death tissues, top fi ve cancers in male mortality were esophagus, stomach, bronchus and lung, liver, brain and central nervous system, and top five of female were esophagus, stomach, bronchus and lung cancer, liver cancer and cervical cancer. As for different landforms cancer mortality, the plain crude mortality rate was 210.69/100 000, China agestandardized mortality rate was 195.58/100 000, and World age-standardized mortality rate was 268.36/100 000. The hilly crude mortality rate was 180.99/100 000, China age-standardized mortality rate was 169.22/100 000, and World age-standardized mortality rate was 228.19/100 000. Mountainous crude mortality rate was 222.83/100 000, China age-standardized mortality rate was 207.84/100 000, and World age-standardized mortality rate was 281.76/100 000. Conclusion Comparison with the historical data of Cixian county, the cancer mortality was increased while esophageal cancer mortality showed declining trend, but it still was the fi rst cancer hazard of death in Cixian. Comparison between different living locations indicated that cancer mortality in mountains was higher than that in plains, that in plains was higher than that in hilly. It would be very important to strengthen comprehensive prevention and control of cancer research??actively and early detect and treat esophageal cancer.