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三药联合化疗方案治疗晚期非小细胞肺癌伴神经内分泌分化的疗效观察

王珍珍, 李珊珊, 路太英, 彭 湃

王珍珍, 李珊珊, 路太英, 彭 湃. 三药联合化疗方案治疗晚期非小细胞肺癌伴神经内分泌分化的疗效观察[J]. 肿瘤防治研究, 2013, 40(10): 980-983. DOI: 10.3971/j.issn.1000-8578.2013.10.016
引用本文: 王珍珍, 李珊珊, 路太英, 彭 湃. 三药联合化疗方案治疗晚期非小细胞肺癌伴神经内分泌分化的疗效观察[J]. 肿瘤防治研究, 2013, 40(10): 980-983. DOI: 10.3971/j.issn.1000-8578.2013.10.016
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WANG Zhenzhen, LI Shanshan, LU Taiying, PENG Pai. Effect of Three-drug Combination Chemotherapy in Advanced Non-small Cell Lung Carcinoma with Neuroendocrine Differentiation Treatment[J]. Cancer Research on Prevention and Treatment, 2013, 40(10): 980-983. DOI: 10.3971/j.issn.1000-8578.2013.10.016
Citation: WANG Zhenzhen, LI Shanshan, LU Taiying, PENG Pai. Effect of Three-drug Combination Chemotherapy in Advanced Non-small Cell Lung Carcinoma with Neuroendocrine Differentiation Treatment[J]. Cancer Research on Prevention and Treatment, 2013, 40(10): 980-983. DOI: 10.3971/j.issn.1000-8578.2013.10.016
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三药联合化疗方案治疗晚期非小细胞肺癌伴神经内分泌分化的疗效观察

  • 450052，郑州大学第一附属医院肿瘤内科

详细信息
    作者简介:

    王珍珍(1987-)，女，硕士在读，主要从事肿瘤内科治疗

    通讯作者:

    路太英，E-mail: wanlucying@163.com

  • 中图分类号: R734.2;R730.53

Effect of Three-drug Combination Chemotherapy in Advanced Non-small Cell Lung Carcinoma with Neuroendocrine Differentiation Treatment

  • Department of Oncology, The First Affi liated Hospital of Zhengzhou University, Zhengzhou 450052, China

摘要

    摘要
  • 摘要: 目的 观察三药联合化疗方案治疗晚期非小细胞肺癌伴神经内分泌分化的近期疗效、远期疗效和不良反应。方法 39例未经治疗的晚期非小细胞肺癌伴神经内分泌分化（NSCLCND）患者中，19例接受紫杉醇+顺铂+依托泊苷（E-TP）三药联合方案，20例接受紫杉醇+顺铂（TP组）两药化疗方案，比较两种化疗方案的近期疗效、远期疗效及不良反应。结果 E-TP组有效率明显高于TP组（47.4% vs.15.0%,P<0.05），疾病控制率E-TP组也明显高于TP组（94.7% vs.70.0%,P<0.05）。E-TP组中位无病生存期较TP组长（P<0.05）。粒细胞减少E-TP组发生率明显高于TP组（P<0.05），其中Ⅲ~Ⅳ度粒细胞减少的发生率高于TP组（P<0.05）。结论 三药联合方案化疗对晚期非小细胞肺癌伴神经内分泌分化的疗效明显优于TP组，不良反应可耐受，可在临床进一步推广。

     

    Abstract: Objective To observe the short-term efficacy, long-term efficacy and adverse reactions of the three-drug combination chemotherapy in the treatment of the advanced non-small cell lung carcinoma with neuroendocrine differentiation(NSCLC-ND). Methods Nineteen patients with NSCLC-ND were treated with three-drug combination of etoposide,paclitaxel and cisplatin chemotherapy (E-TP group) and twenty patients were treated with two-drug combination of paclitaxel and cisplatin chemotherapy (TP group) . Short-term effi cacy, long-term effi cacy and adverse reaction of two chemotherapies were compared. Results The effi ciency of E-TP group was signifi cantly higher than that of TP group(47.4% vs. 15.0%，P<0.05). The disease control rate of E-TP group was apparently higher than that of TP group(94.7% vs. 70.0%,P<0.05). The median disease free survival of E-TP group was longer than that of TP group(P<0.05). The neutropenia incidence of E-TP group was signifi cantly higher than that of TP group, especially in the Ⅲ-Ⅳ degree(P<0.05). Conclusion The threedrug combination chemotherapy had higher effi cacy than TP combination in the treatment of advanced nonsmall cell lung carcinoma with neuroendocrine differentiation, and the adverse reactions could be tolerated. The three-drug combination chemotherapy could be further promoted.

     

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  • [1] Skov BG,Sorensen JB,Hirsch FR,et al.Prognostic impact of histologic demonstration of chromogranin A and neuron specific enolase in pulmonary adenocacinoma[J].Ann oncol,1991,2(5):355-60.
    [2] Graziano SL,Tatum AH,Newman NB,et al.The prognostic significance of neuroendocrine markers and carcinoembryonic antigen in patients with resected stage and non-small lung cancer[J].Cancer Res,1994,54(11):2908-13.
    [3] Schleusener JT,Tazelaar HD,Jung SH,et al.Nerroendocrine differentiation is an independent prognostic factor in chemotherapy-treated nonsmall cell lung carcinoma[J].Cancer,19 96,77(7):1284-91.
    [4] Howe MC,Chapman A ,Kerr K,et al.Neuroendocrine differentiation in non-small cell lung cancer and its relation to prognosis and therapy[J].Histoppathology,2005,46(2):195-201.
    [5] González-Aragoneses F,Moreno-Mata N,Cebollero-Presnanes M,et al.Prognostic signifi cance of synaptophysin in stage I of squamous carcinoma and addenocarcinoma of the lung[J].Cancer,2007,110 (8):1776-81.
    [6] Dai L,Sun Y,Li XH,et al.Nerroendocrine differentiation is not a malignant index of non-small cell lung cancer[J].Zhongguo Fei Ai Za Zhi,2011,14(8):646-52.[戴亮,孙宇,李向红,等.神经内分 泌分化不是非小细胞肺癌高恶性度的指标[J].中国肺癌杂 志,2011,14(8):646-52.]
    [7] Dong N,Sun LN,Zhan ZL,et al.The relationgship between the biological characteristics of squamous cell lung cancer of neuroendocrine-like differentiation and its prognosis[J].Zhongguo Zhong Liu Lin Chuang, 2009,36(20):1171-5.[董娜,孙蕾娜,战忠 利,等.肺鳞状细胞癌伴神经内分泌分化与生物学特性及预后关 系探讨[J].中国肿瘤临床,2009,36(20):1171-5.]
    [8] Wang PY,Zhao HL,et al. The clinical observation of the EP and TP combined with radiotherapy in the treatment of stage Ⅲ nonsmall cell lung cancer[J].Yiyao lun Tan Za Zhi,2010,31(3):7-9.[王 鹏远,赵宏亮.EP与TP方案化放疗治疗Ⅲ期非小细胞肺癌疗效 观察[J].医药论坛杂志,2010,31(3):7-9.]
    [9] Bomomi P,Kim K,Fairclough D,et al. Comparison of survival and quality of life in advanced non-small cell lung cancer patients treated with two dose levels of pacilitaxel combined with cisplatin versus etoposide with cisplatin: result of an Eastern Cooperative Oncology Group tirial[J].J Clin Oncol,2000,18(3):623-31.
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出版历程
  • 收稿日期:  2012-10-14
  • 修回日期:  2012-12-16
  • 刊出日期:  2013-10-24

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